1990
MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neuroscience Letters 1990, 114: 316-322. PMID: 2402341, DOI: 10.1016/0304-3940(90)90583-u.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDopamine innervationMotor areaParkinson's diseaseMPTP-induced degenerationStriatal dopamine innervationStriatal dopamine concentrationsAsymptomatic MPTPSymptomatic MPTPConcentration of dopamineNorepinephrine levelsNorepinephrine concentrationsCortical involvementDopaminergic innervationCingulate sulcusCingulate cortexMPTPCortical regionsDopamine concentrationsInnervationDiseaseDopamineBehavioral changesCortexDegeneration
1988
Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients
Goldstein M, Lieberman A, Helmer E, Koslow M, Ransohoff J, Elsworth J, Roth R, Deutch A. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Annals Of Neurology 1988, 24: 685-688. PMID: 2904793, DOI: 10.1002/ana.410240517.Peer-Reviewed Original ResearchConceptsBiopsy samplesAdrenal transplantationDopamine functionAutologous adrenal transplantationMetabolite homovanillic acidEnzyme tyrosine hydroxylaseConcentration of dopamineParkinsonian patientsTherapeutic responseHomovanillic acidParkinson's diseaseTyrosine hydroxylasePostmortem valuesBiochemical analysisBiochemical parametersPatientsTransplantationPostmortem changesDisease