2024
Use of Sensitivity Analyses to Assess Uncontrolled Confounding from Unmeasured Variables in Observational, Active Comparator Pharmacoepidemiologic Studies: A Systematic Review
Latour C, Delgado M, Su I, Wiener C, Acheampong C, Poole C, Edwards J, Quinto K, Stürmer T, Lund J, Li J, Lopez N, Concato J, Funk M. Use of Sensitivity Analyses to Assess Uncontrolled Confounding from Unmeasured Variables in Observational, Active Comparator Pharmacoepidemiologic Studies: A Systematic Review. American Journal Of Epidemiology 2024, kwae234. PMID: 39098826, DOI: 10.1093/aje/kwae234.Peer-Reviewed Original ResearchUncontrolled confoundingEpidemiology journalsResidual confoundingSystematic reviewRobustness of studiesComparative cohort studyActive comparator cohort studyMedical journal articlesCohort studyConfoundingJournal articlesPharmacoepidemiological studiesSensitivity analysisPotential biasAssess robustnessMeasured variablesUnmeasured variablesPotential concernReview articleStudyJournalsVariables
2023
Metformin prescription for U.S. veterans with prediabetes, 2010–2019
Gulanski B, Goulet J, Radhakrishnan K, Ko J, Li Y, Rajeevan N, Lee K, Heberer K, Lynch J, Streja E, Mutalik P, Cheung K, Concato J, Shih M, Lee J, Aslan M. Metformin prescription for U.S. veterans with prediabetes, 2010–2019. Journal Of Investigative Medicine 2023, 72: 139-150. PMID: 37668313, DOI: 10.1177/10815589231201141.Peer-Reviewed Original ResearchConceptsBody mass indexVeterans Health AdministrationIncident prediabetesHigh riskHealth AdministrationRetrospective observational cohort studyType 2 diabetes mellitusUse of metforminObservational cohort studyProportion of veteransMetformin prescribingGestational diabetesCohort studyMetformin prescriptionDiabetes mellitusDiabetes preventionMass indexCardiovascular diseaseMultivariable modelPrediabetesSubset of individualsMetforminU.S. veteransHealthcare systemVeterans
2015
Million Veteran Program: A mega-biobank to study genetic influences on health and disease
Gaziano JM, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, Whitbourne S, Deen J, Shannon C, Humphries D, Guarino P, Aslan M, Anderson D, LaFleur R, Hammond T, Schaa K, Moser J, Huang G, Muralidhar S, Przygodzki R, O'Leary TJ. Million Veteran Program: A mega-biobank to study genetic influences on health and disease. Journal Of Clinical Epidemiology 2015, 70: 214-223. PMID: 26441289, DOI: 10.1016/j.jclinepi.2015.09.016.Peer-Reviewed Original ResearchConceptsMillion Veteran ProgramVeterans Affairs Health Care SystemObservational cohort studyVA electronic health recordVeteran ProgramHealth care deliverySelf-reported raceHealth care systemElectronic health recordsCohort studyAfrican American populationBlood samplesPeer-reviewed research studiesCare deliveryClinical decisionGenetic testingStudy designRecruiting sitesCare systemHealth recordsMost participantsPrecision medicineGenetic influencesAmerican populationParticipants
2013
Design of “Neuropsychological and Mental Health Outcomes of Operation Iraqi Freedom: A Longitudinal Cohort Study”
Aslan M, Concato J, Peduzzi P, Proctor S, Schnurr P, Marx B, McFall M, Gleason T, Huang G, Vasterling J. Design of “Neuropsychological and Mental Health Outcomes of Operation Iraqi Freedom: A Longitudinal Cohort Study”. Journal Of Investigative Medicine 2013, 61: 569. DOI: 10.231/jim.0b013e31828407ff.Peer-Reviewed Original ResearchNeurocognition Deployment Health StudyPosttraumatic stress disorderOperation Iraqi FreedomStudy designVA Cooperative Studies ProgramSubsequent posttraumatic stress disorderLongitudinal cohort studyStatistical analysis planTraumatic brain injuryMental health disordersTarget sample sizeCooperative Studies ProgramIraqi FreedomTiming of assessmentMental health outcomesCurrent study dataUS Army soldiersCohort studyBrain injuryStudy populationHealth StudyPostdeployment assessmentsHealth disordersNeuropsychological changesHealth outcomes
2002
The Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review
Reid M, Boutros N, O'Connor P, Cadariu A, Concato J. The Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review. Substance Use & Addiction Journal 2002, 23: 149-164. PMID: 12444348, DOI: 10.1080/08897070209511485.Peer-Reviewed Original ResearchConceptsCause mortalityCognitive impairmentExposure statusFunctional disabilityAlcohol useOlder adultsFunctional impairmentMiddle-aged adult populationParticipants 60 yearsYears of ageEnglish-language studiesExposure-outcome associationsImportant confounding factorsHealth-related effectsEffects of alcoholMagnitude of riskCohort studySubstantial morbidityPercentage of studiesFormer drinkersProspective studyMean ageAlcohol exposureMethodologic qualityOutcome measures
1997
Screening for Skin Cancer in Primary Care Settings
Federman D, Concato J, Caralis P, Hunkele G, Kirsner R. Screening for Skin Cancer in Primary Care Settings. JAMA Dermatology 1997, 133: 1423-1425. PMID: 9371027, DOI: 10.1001/archderm.1997.03890470101016.Peer-Reviewed Original ResearchConceptsPrimary care settingSkin examinationSkin cancerCare settingsFecal occult blood testingRetrospective observational cohort studyVeterans Affairs Medical CenterOccult blood testingObservational cohort studyPrimary care visitsMedical record reviewSkin cancer screeningOutpatient medical clinicSkin-related complaintsCare visitsCohort studyAmbulatory visitsRecord reviewRectal examinationBlood testingPhysical examinationCancer screeningProstate examinationMedical CenterMAIN OUTCOME
1992
Problems of Comorbidity in Mortality After Prostatectomy
Concato J, Horwitz R, Feinstein A, Elmore J, Schiff S. Problems of Comorbidity in Mortality After Prostatectomy. JAMA 1992, 267: 1077-1082. PMID: 1370963, DOI: 10.1001/jama.1992.03480080047025.Peer-Reviewed Original ResearchConceptsBenign prostatic hyperplasiaLong-term mortalityTime of surgeryTreatment of BPHOpen prostatectomyTURP groupOpen groupHigher long-term mortalityYale-New Haven HospitalClassifications of comorbidityRetrospective cohort studyFive-year mortalityAssessment of comorbiditiesSeverity of illnessProblem of comorbidityAdjusted riskComorbid illnessesCohort studyTransurethral resectionProstatic hyperplasiaPatient outcomesMortality ratePatientsProstatectomyHigh mortality