2003
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson HM, Warr CG, Carlson JR. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14537-14542. PMID: 14608037, PMCID: PMC304115, DOI: 10.1073/pnas.2335847100.Peer-Reviewed Original ResearchConceptsMolecular evolutionDrosophila melanogasterGustatory receptor proteinsAlternative splice formsN-terminal exonsGR geneChemoreceptor genesTandem clustersAncestral intronsAncient superfamilyDrosophila genomeIntron evolutionDivergent cladesAdditional intronPolymorphic pseudogenesInsect chemoreceptorCommon ancestorAlternative splicingPhylogenetic analysisGR familyOdorant receptorsSplice formsX chromosomeSugar trehaloseIntrons
2000
Candidate Taste Receptors in Drosophila
Clyne P, Warr C, Carlson J. Candidate Taste Receptors in Drosophila. Science 2000, 287: 1830-1834. PMID: 10710312, DOI: 10.1126/science.287.5459.1830.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlternative SplicingAmino Acid SequenceAnimalsChemoreceptor CellsDrosophila melanogasterDrosophila ProteinsExonsGene ExpressionGenes, InsectIn Situ HybridizationInsect ProteinsMembrane ProteinsMolecular Sequence DataMultigene FamilyNeurons, AfferentOrgan SpecificityProtein Structure, TertiaryReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSense OrgansSequence AlignmentTasteConceptsDrosophila genome databaseTransmembrane domain proteinCandidate taste receptorsDomain proteinsDrosophila mutantsDivergent familiesGenome databaseTaste receptorsTissue specificityMolecular mechanismsDiverse familyGustatory organsGenesStructural similarityLabellumBasis of structureTaste signalingProteinTaste neuronsInitial eventFamilyExpressionDrosophilaMutantsReceptors
1999
A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila
Clyne P, Warr C, Freeman M, Lessing D, Kim J, Carlson J. A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila. Neuron 1999, 22: 327-338. PMID: 10069338, DOI: 10.1016/s0896-6273(00)81093-4.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsPOU domain transcription factorLarge multigene familyCandidate odorant receptorsTransmembrane domain proteinGenomic sequence databasesSubset of ORNsDomain proteinsMultigene familyAntennal developmentOdorant receptorsTranscription factorsSequence databasesInitiate expressionOlfactory organOdorant specificityNovel familyDifferent membersReceptor neuronsReceptor moleculesInsectsMutantsValuable modelGenesOlfactory system