2023
Diverse mechanisms of taste coding in Drosophila
Dweck H, Carlson J. Diverse mechanisms of taste coding in Drosophila. Science Advances 2023, 9: eadj7032. PMID: 37976361, PMCID: PMC10656072, DOI: 10.1126/sciadv.adj7032.Peer-Reviewed Original Research
2022
Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila
Xiao S, Baik LS, Shang X, Carlson JR. Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204238119. PMID: 35700364, PMCID: PMC9231609, DOI: 10.1073/pnas.2204238119.Peer-Reviewed Original ResearchConceptsGenerations of exposureDipteran speciesAnthropogenic stressorsGR familyEnvironmental changesToxic chemical compoundsBitter-sensing neuronsTaste organsTaste receptorsAvoidance of feedingSugar-sensing neuronsElevated concentrationsZinc ionsDrosophilaChemical compoundsInsectsHuman activitiesBehavioral responsesReceptorsOrganismsFliesSpeciesNeuronsRapid rateDifferent subsetsIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2021
Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii
Dweck HK, Talross GJ, Wang W, Carlson JR. Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. ELife 2021, 10: e64317. PMID: 33616529, PMCID: PMC7899650, DOI: 10.7554/elife.64317.Peer-Reviewed Original ResearchConceptsFruit pest Drosophila suzukiiRipe fruitPest Drosophila suzukiiEvolutionary shiftsBitter compoundsLays eggsAgricultural pestsDrosophila suzukiiBitter taste perceptionDrosophilaTaste sensillaSpeciesPhysiological responsesReduced expressionEggsTaste organsSensillaOverripe fruitsFruitTranscriptomeTaste codingSuzukiiMutantsLabellumPests
2020
The mosquito taste system and disease control
Baik LS, Carlson JR. The mosquito taste system and disease control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32848-32856. PMID: 33372129, PMCID: PMC7776869, DOI: 10.1073/pnas.2013076117.Peer-Reviewed Original ResearchConceptsVectors of diseaseNew mechanistic insightsMosquito olfactionGeographical rangeVector speciesMechanistic insightsSpeciesMosquito controlAfflict hundredsDiverse groupCurrent knowledgeWealth of opportunitiesMosquitoesClimate changeTaste systemInsectsEnormous rangeHabitatsUnderstanding of tasteOrganismsEggsNew strategyOlfactionTechnological advancesUnderstanding
2019
Molecular Logic and Evolution of Bitter Taste in Drosophila
Dweck HKM, Carlson JR. Molecular Logic and Evolution of Bitter Taste in Drosophila. Current Biology 2019, 30: 17-30.e3. PMID: 31839451, PMCID: PMC6946858, DOI: 10.1016/j.cub.2019.11.005.Peer-Reviewed Original ResearchChemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor
He Z, Luo Y, Shang X, Sun JS, Carlson JR. Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor. PLOS Biology 2019, 17: e2006619. PMID: 31112532, PMCID: PMC6528970, DOI: 10.1371/journal.pbio.2006619.Peer-Reviewed Original ResearchConceptsMale-female interactionsDrosophila wingSubesophageal zoneWing marginChemosensory sensillaRNA-seq analysisDifferential RNA-seq analysisAnterior wing marginMale-male interactionsPheromone receptorsTaste organsOptogenetic activationMolecular descriptionGenesIonotropic receptorsChemical perceptionSensillaSecond-order projectionsSexual behaviorFliesPheromoneMale sexual behaviorPheromonal inputHydrophobic moleculesActivation
2017
A receptor and neuron that activate a circuit limiting sucrose consumption
Joseph RM, Sun JS, Tam E, Carlson JR. A receptor and neuron that activate a circuit limiting sucrose consumption. ELife 2017, 6: e24992. PMID: 28332980, PMCID: PMC5388533, DOI: 10.7554/elife.24992.Peer-Reviewed Original Research
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship
2011
The Molecular and Cellular Basis of Bitter Taste in Drosophila
Weiss LA, Dahanukar A, Kwon JY, Banerjee D, Carlson JR. The Molecular and Cellular Basis of Bitter Taste in Drosophila. Neuron 2011, 69: 258-272. PMID: 21262465, PMCID: PMC3033050, DOI: 10.1016/j.neuron.2011.01.001.Peer-Reviewed Original Research
2007
Two Gr Genes Underlie Sugar Reception in Drosophila
Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr Genes Underlie Sugar Reception in Drosophila. Neuron 2007, 56: 503-516. PMID: 17988633, PMCID: PMC2096712, DOI: 10.1016/j.neuron.2007.10.024.Peer-Reviewed Original ResearchConceptsSubset of sugarsReporter gene expressionSugar-sensing neuronsDouble mutantSugar receptionMolecular basisGenetic analysisGene expressionGr5aDrosophilaReceptor geneSitu hybridizationGenesNeuronsGr64aPrimary receptorTaste receptorsDistinct projectionsReceptorsTemporal dynamicsSugarsMutantsBehavioral responsesLabellumReporter
2006
Insects as chemosensors of humans and crops
van der Goes van Naters W, Carlson JR. Insects as chemosensors of humans and crops. Nature 2006, 444: 302-307. PMID: 17108954, DOI: 10.1038/nature05403.Peer-Reviewed Original Research
2003
Drosophila Gr5a encodes a taste receptor tuned to trehalose
Chyb S, Dahanukar A, Wickens A, Carlson JR. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14526-14530. PMID: 14523229, PMCID: PMC304113, DOI: 10.1073/pnas.2135339100.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor genesDrosophila S2 cell lineS2 cell lineFirst functional expressionTaste receptorsHeterologous expressionGenetic analysisFunctional expressionGr5aTaste sensillaReceptor geneCell linesGenesLabellar sensillaExpressionSensillaTaste neuronsReceptorsRecent studiesLabellumSensory responsesFliesNeuronsTrehaloseFamilyMolecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson HM, Warr CG, Carlson JR. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14537-14542. PMID: 14608037, PMCID: PMC304115, DOI: 10.1073/pnas.2335847100.Peer-Reviewed Original ResearchConceptsMolecular evolutionDrosophila melanogasterGustatory receptor proteinsAlternative splice formsN-terminal exonsGR geneChemoreceptor genesTandem clustersAncestral intronsAncient superfamilyDrosophila genomeIntron evolutionDivergent cladesAdditional intronPolymorphic pseudogenesInsect chemoreceptorCommon ancestorAlternative splicingPhylogenetic analysisGR familyOdorant receptorsSplice formsX chromosomeSugar trehaloseIntrons
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members
2000
Candidate Taste Receptors in Drosophila
Clyne P, Warr C, Carlson J. Candidate Taste Receptors in Drosophila. Science 2000, 287: 1830-1834. PMID: 10710312, DOI: 10.1126/science.287.5459.1830.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlternative SplicingAmino Acid SequenceAnimalsChemoreceptor CellsDrosophila melanogasterDrosophila ProteinsExonsGene ExpressionGenes, InsectIn Situ HybridizationInsect ProteinsMembrane ProteinsMolecular Sequence DataMultigene FamilyNeurons, AfferentOrgan SpecificityProtein Structure, TertiaryReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSense OrgansSequence AlignmentTasteConceptsDrosophila genome databaseTransmembrane domain proteinCandidate taste receptorsDomain proteinsDrosophila mutantsDivergent familiesGenome databaseTaste receptorsTissue specificityMolecular mechanismsDiverse familyGustatory organsGenesStructural similarityLabellumBasis of structureTaste signalingProteinTaste neuronsInitial eventFamilyExpressionDrosophilaMutantsReceptors