2015
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans
Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Neuropsychopharmacology 2015, 40: 2813-2821. PMID: 25948103, PMCID: PMC4864657, DOI: 10.1038/npp.2015.131.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCognition DisordersCotinineFemaleGenome-Wide Association StudyHeart RateHumansMaleMiddle AgedNerve Tissue ProteinsNeuropsychological TestsNicotineNicotinic AgonistsPolymorphism, Single NucleotideReceptors, NicotinicSmokingSubstance Withdrawal SyndromeSurveys and QuestionnairesConceptsAversive effectsHeavy smokingRisk allelesSmoking-related disordersAfrican American smokersCHRNA5-CHRNA3Doses of nicotineHigh nicotine doseNicotine administrationIntravenous doseNicotine effectsNicotine doseAmerican smokersWithdrawal severityOvernight abstinenceAcute responseAA subjectsCardiovascular reactivityCHRNB4 gene clusterNicotineEuropean AmericansAversive responsesAdministration sessionsSmokingCognitive performance
2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effects