2021
The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C
Dao C, Zhou H, Small A, Gordon KS, Li B, Kember RL, Ye Y, Gelernter J, Xu K, Kranzler HR, Zhao H, Justice AC. The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C. Addiction 2021, 116: 3044-3054. PMID: 33861876, PMCID: PMC9377185, DOI: 10.1111/add.15511.Peer-Reviewed Original Research
2008
Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence
Yang B, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. Alcohol Clinical And Experimental Research 2008, 32: 2117-2127. PMID: 18828801, PMCID: PMC2975565, DOI: 10.1111/j.1530-0277.2008.00800.x.Peer-Reviewed Original Research
2007
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples. Human Molecular Genetics 2007, 16: 2844-2853. PMID: 17761687, DOI: 10.1093/hmg/ddm240.Peer-Reviewed Original Research
2006
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Human Molecular Genetics 2006, 15: 3498-3507. PMID: 17085484, DOI: 10.1093/hmg/ddl426.Peer-Reviewed Original ResearchAdultAllelesBlack or African AmericanBlack PeopleCocaine-Related DisordersFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedNeural Cell Adhesion MoleculesOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Dopamine D2Tobacco Use DisorderWhite PeopleC957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
Jacobsen LK, Pugh KR, Mencl WE, Gelernter J. C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology 2006, 188: 530-540. PMID: 16896957, DOI: 10.1007/s00213-006-0469-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDouble-Blind MethodFemaleGenotypeHumansMaleMemoryNicotineNicotinic AgonistsPolymorphism, GeneticReceptors, Dopamine D2SmokingConceptsMemory performanceEffects of nicotineBrain regionsBrain functionFunctional magnetic resonanceCortical processing efficiencyRange of behavioralC957T polymorphismProcessing efficiencyPhonological rehearsalMemory taskMemory loadBrain responsesPerformance accuracyC957TMemoryBehavioral effectsNicotine administrationDopamine D2 receptor geneConclusionsThese findingsTobacco dependenceIndividual variationIndividual responsesTaskPlacebo patch
2000
Family‐Based study of DRD2 alleles in alcohol and drug dependence
Blomqvist O, Gelernter J, Kranzler H. Family‐Based study of DRD2 alleles in alcohol and drug dependence. American Journal Of Medical Genetics 2000, 96: 659-664. PMID: 11054774, DOI: 10.1002/1096-8628(20001009)96:5<659::aid-ajmg12>3.0.co;2-g.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAllelesDNAFamily HealthFemaleGene FrequencyHumansMaleNuclear FamilyPolymorphism, GeneticReceptors, Dopamine D2Substance-Related DisordersConceptsCase-control studyDrug dependenceAlcohol dependenceFamily-based studySubstance dependenceRecent family-based studyNumerous case-control studiesDSM-IV criteriaDopamine D2 receptor geneDRD2 allelesPresent studyD2 receptor geneDSM-IIIVariant allelesTransmission disequilibrium testConflicting resultsReceptor geneNegative resultsPositive associationEuropean AmericansTaqI AEuropean ancestryLinkage disequilibriumDisequilibrium testSmall nuclear families
1999
D2 Dopamine Receptor Gene (DRD2) Allele and Haplotype Frequencies in Alcohol Dependent and Control Subjects: No Association with Phenotype or Severity of Phenotype
Gelernter J, Kranzler H. D2 Dopamine Receptor Gene (DRD2) Allele and Haplotype Frequencies in Alcohol Dependent and Control Subjects: No Association with Phenotype or Severity of Phenotype. Neuropsychopharmacology 1999, 20: 640-649. PMID: 10327432, DOI: 10.1016/s0893-133x(98)00110-9.Peer-Reviewed Original ResearchAlcoholismAllelesGene FrequencyGenotypeHaplotypesHumansLinkage DisequilibriumPhenotypeReceptors, Dopamine D2No association between D2 dopamine receptor (DRD2) “A” system alleles, or DRD2 haplotypes, and posttraumatic stress disorder
Gelernter J, Southwick S, Goodson S, Morgan A, Nagy L, Charney D. No association between D2 dopamine receptor (DRD2) “A” system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biological Psychiatry 1999, 45: 620-625. PMID: 10088049, DOI: 10.1016/s0006-3223(98)00087-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesFemaleGenetic VariationHaplotypesHumansMaleMiddle AgedPolymorphism, GeneticReceptors, Dopamine D2Stress Disorders, Post-TraumaticNo association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans
Gelernter J, Kranzler H, Satel S. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Biological Psychiatry 1999, 45: 340-345. PMID: 10023512, DOI: 10.1016/s0006-3223(97)00537-4.Peer-Reviewed Original ResearchAllelesBehavior, AddictiveBlack PeopleCase-Control StudiesChi-Square DistributionCocaine-Related DisordersComputer SimulationFemaleGene DosageGenetic MarkersGenetic Predisposition to DiseaseHaplotypesHumansLinkage DisequilibriumMalePolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Severity of Illness IndexWhite People
1998
Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))
Gelernter J, Kranzler H, Lacobelle J. Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF)). Genomics 1998, 52: 289-297. PMID: 9790747, DOI: 10.1006/geno.1998.5454.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApolipoproteins ECarrier ProteinsCiliary Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsGenetics, PopulationGenotypeHumansMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPolymorphism, GeneticReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Opioid, muTryptophan HydroxylaseConceptsCiliary neurotrophic factorDRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects
Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects. Genomics 1998, 51: 21-26. PMID: 9693029, DOI: 10.1006/geno.1998.5264.Peer-Reviewed Original ResearchConceptsLinkage disequilibriumFunctional variantsSignificant linkage disequilibriumMutational analysis studiesFirst intronKb 5Linkage disequilibriaFrequencies of haplotypesPopulation stratificationGenetic associationDrd2 promoterPhysiological basisAllele frequenciesPhysiological relationshipGenesReceptor allelesEuropean-American subjectsD2 dopamine receptor (DRD2) allelesDisequilibriumBehavioral phenotypesPhenotypeFunctional meaningEuropean originVariantsAmerican populationD2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
Laruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Molecular Psychiatry 1998, 3: 261-265. PMID: 9672902, DOI: 10.1038/sj.mp.4000343.Peer-Reviewed Original ResearchConceptsD2 receptor expressionD2 receptor geneReceptor expressionD2 receptorsA1 alleleLower D2 receptor expressionReceptor geneSubstance abuseB1 alleleLow D2 receptor densityD2 receptor densityD2 receptor radiotracerReceptor-binding potentialSingle photon emissionPostmortem studiesA1 carriersReceptor radiotracerTaq1 polymorphismReceptor densityCaudate nucleusDopamine transmissionPossible associationPhoton emissionAlcoholismReceptors
1997
D4 Dopamine-Receptor (DRD4) Alleles and Novelty Seeking in Substance-Dependent, Personality-Disorder, and Control Subjects
Gelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew CL. D4 Dopamine-Receptor (DRD4) Alleles and Novelty Seeking in Substance-Dependent, Personality-Disorder, and Control Subjects. American Journal Of Human Genetics 1997, 61: 1144-1152. PMID: 9345090, PMCID: PMC1716050, DOI: 10.1086/301595.Peer-Reviewed Original Research
1994
Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine
Rao PA, Pickar D, Gejman PV, Ram A, Gershon ES, Gelernter J. Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine. JAMA Psychiatry 1994, 51: 912-917. PMID: 7944879, DOI: 10.1001/archpsyc.1994.03950110072009.Peer-Reviewed Original ResearchConceptsClinical responseTherapeutic effectAtypical antipsychotic drug clozapineClozapine's therapeutic effectsTreatment-refractory schizophreniaPathophysiology of schizophreniaAntipsychotic drug clozapineD4 dopamine receptorsDRD4 allelesPutative third cytoplasmic loopSchizoaffective patientsTherapeutic responseTherapy variesDopamine receptorsSchizoaffective subjectsTreatment responseThird cytoplasmic loopDrug clozapineClozapineDopamine receptor geneSchizoaffective disorderD4 receptorsPolymerase chain reaction amplificationReceptor allelesChain reaction amplificationNo structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.
Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble EP, Kranzler HR, O'Malley S. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 1994, 271: 204-8. PMID: 8277546, DOI: 10.1001/jama.271.3.204.Peer-Reviewed Original Research
1993
The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal.
Gelernter J, Goldman D, Risch N. The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA 1993, 269: 1673-7. PMID: 8095994, DOI: 10.1001/jama.269.13.1673.Peer-Reviewed Original Research
1992
The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
Gelernter J, Kennedy JL, van Tol H, Civelli O, Kidd KK. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 1992, 13: 208-210. PMID: 1349574, DOI: 10.1016/0888-7543(92)90222-e.Peer-Reviewed Original ResearchLinkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM
Gelernter J, Pakstis AJ, Grandy D, Litt M, Retief AE, Kennedy JL, Hing-Loh A, Schoolfield G, Civelli O, Kidd KK. Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM. Cytogenetic And Genome Research 1992, 60: 26-28. PMID: 1349858, DOI: 10.1159/000133287.Peer-Reviewed Original Research