2006
γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment
Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.Peer-Reviewed Original ResearchConceptsBrain GABA systemsGABA systemAlcohol dependenceWithdrawal symptomsGABA functionGamma-aminobutyric acid (GABA) functionCortical GABA levelsAlcohol withdrawal symptomsΓ-Aminobutyric Acid Type A ReceptorsEnvironmental risk factorsLong-term alcohol effectsType A ReceptorsAlcohol-dependent individualsLong-term sobrietyGABA releaseNeurosteroid levelsAcute withdrawalAlcoholism vulnerabilityGABA neurotransmissionRisk factorsGABA levelsExtrasynaptic locationsLow chloride conductanceReceptor densityTonic component
1998
D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
Laruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Molecular Psychiatry 1998, 3: 261-265. PMID: 9672902, DOI: 10.1038/sj.mp.4000343.Peer-Reviewed Original ResearchConceptsD2 receptor expressionD2 receptor geneReceptor expressionD2 receptorsA1 alleleLower D2 receptor expressionReceptor geneSubstance abuseB1 alleleLow D2 receptor densityD2 receptor densityD2 receptor radiotracerReceptor-binding potentialSingle photon emissionPostmortem studiesA1 carriersReceptor radiotracerTaq1 polymorphismReceptor densityCaudate nucleusDopamine transmissionPossible associationPhoton emissionAlcoholismReceptors