2021
Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD Pathogenesis
Wingo T, Gerasimov E, Liu Y, Duong D, Lori A, Gockley J, Toikumo S, Breen M, Maihofer A, Nievergelt C, Koenen K, Ressler K, Levey D, Gelernter J, Stein M, Bennett D, Levey A, Seyfried N, Wingo A. Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD Pathogenesis. Biological Psychiatry 2021, 89: s102-s103. DOI: 10.1016/j.biopsych.2021.02.265.Peer-Reviewed Original Research
2002
Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression
Cubells J, Zabetian C, Anderson G, Price L, Meyers B, Malison R, Nelson J, Nagatsu T, Ichinose H, Gelernter J. Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression. Advances In Behavioral Biology 2002, 53: 423-426. DOI: 10.1007/978-1-4757-3538-3_101.Peer-Reviewed Original ResearchDβH proteinEnzyme activityMolecular genetic analysisBiochemical traitsGenetic analysisMajor locusNeurosecretory vesiclesGenetic inheritanceΒ-hydroxylaseDopamine β-hydroxylaseTraitsNeurosecretory cellsProteinDβH levelsConversion of dopamineLociVesiclesPlasma dopamine β-hydroxylaseInheritanceMembraneActivityCells
1995
Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17
Gelernter J, Pakstis AJ, Kidd KK. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Human Genetics 1995, 95: 677-680. PMID: 7789954, DOI: 10.1007/bf00209486.Peer-Reviewed Original ResearchConceptsRestriction fragment length polymorphismTransporter proteinsTransporter protein geneSerotonin transporter protein geneNorepinephrine transporter proteinLinkage mapLinkage mappingProtein geneChromosome 16q21Genetic lociCandidate genesUntranslated regionFragment length polymorphismChromosome 17GenesLinkage resultsSitu hybridizationGene SLC6A4Length polymorphismLinkage studiesPCR productsProximal 17qProteinLogical candidate geneSLC6A4
1993
Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16
Gelernter J, Kruger S, Pakstis A, Pacholczyk T, Sparkes R, Kidd K, Amara S. Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16. Genomics 1993, 18: 690-692. PMID: 7905857, DOI: 10.1016/s0888-7543(05)80375-1.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsChromosome MappingChromosomes, Human, Pair 16Deoxyribonucleases, Type II Site-SpecificDNA, ComplementaryGenetic LinkageGenetic MarkersHumansNorepinephrineNorepinephrine Plasma Membrane Transport ProteinsPolymorphism, Restriction Fragment LengthRestriction MappingSymportersConceptsNorepinephrine transporter proteinSomatic cell hybrid panelCell hybrid panelHybrid panelHP locusCEPH familiesLarge multigenerational familyTransporter proteinsLinkage analysisChromosome 16Provisional assignmentLinkage dataLociMultigenerational familiesGenetic polymorphismsSite of actionPreliminary assignmentNet1FamilyProteinRFLPSitesPolymorphismPCRLocalization