2024
Human genetics and epigenetics of alcohol use disorder
Zhou H, Gelernter J. Human genetics and epigenetics of alcohol use disorder. Journal Of Clinical Investigation 2024, 134: e172885. PMID: 39145449, PMCID: PMC11324314, DOI: 10.1172/jci172885.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesEWAS studiesPower of GWASTranscriptome-wide associationGenome-wide scanAlcohol use disorderWhole-genome sequencingDrug-gene interactionsSingle-cell sequencingAssociation studiesDownstream analysisHuman geneticsGenetic variantsEpigenetic risk factorsVariant functionEpigenetic changesSpatial transcriptomicsUse disorderEpigeneticsDisease risk predictionGenetic correlationsDiversity of populationGeneticsComplex etiologyEnvironmental factors
2021
Integration of evidence across human and model organism studies: A meeting report
Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca‐Bachman C, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Bin Kwon S, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez‐Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. Integration of evidence across human and model organism studies: A meeting report. Genes Brain & Behavior 2021, 20: e12738. PMID: 33893716, PMCID: PMC8365690, DOI: 10.1111/gbb.12738.Peer-Reviewed Original ResearchModel organism studiesModel organismsOrganism studiesDeeper mechanistic insightsPhenotypic dataGenomic researchOmics dataHuman geneticsMechanistic insightsEpigeneticsComputational biologyDiverse groupGeneticsBiological sciencesOrganismsBiologySpeciesHumansFair Data SharingData integrationCurrent toolsNew opportunitiesFundamental gap