2014
GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
Chung D, Yang C, Li C, Gelernter J, Zhao H. GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation. PLOS Genetics 2014, 10: e1004787. PMID: 25393678, PMCID: PMC4230845, DOI: 10.1371/journal.pgen.1004787.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesFunctional annotationGWAS datasetsAnnotation informationStatistical approachMultiple GWAS datasetsGenome-wide markersPowerful statistical methodsSingle-phenotype analysisCentral nervous system genesRisk variantsNervous system genesGenotype-Tissue Expression (GTEx) databaseComplex diseasesGWAS data setsSignificant pleiotropic effectsCommon risk basisDifferent complex diseasesDNase-seq dataCell linesStatistical inferenceGenetic architectureGWAS hitsGWAS resultsNovel statistical approach
2013
Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence
Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence. American Journal Of Human Genetics 2013, 93: 1027-1034. PMID: 24268660, PMCID: PMC3853414, DOI: 10.1016/j.ajhg.2013.10.021.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesHuman protein interaction networkGene subnetworksProtein interaction networksIntegrating Genome-Wide Association StudyInteraction networksHuman complex disordersSubnetworks of genesGWAS data setsFunctional enrichment analysisAD risk genesEnrichment analysisProtein productsAssociation studiesSignificant genetic contributionGenesGenetics of AlcoholismStudy of AddictionGenetic contributionGeneticsComplex disorderAD etiologyCation transportImportant cluesEuropean descentGenome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry 2013, 19: 717-723. PMID: 23958962, PMCID: PMC3865158, DOI: 10.1038/mp.2013.99.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCDC2 Protein KinaseCocaineCocaine-Related DisordersCyclin-Dependent KinasesDopamine Uptake InhibitorsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotyping TechniquesHumansMaleNuclear Receptor Co-Repressor 2Paranoid DisordersPolymorphism, Single NucleotideUnited StatesWhite PeopleConceptsGenome-wide association studiesAssociation studiesAvailable GWAS dataSignificant GWAS SNPsNovel risk lociGWAS data setsSame chromosomal regionDiscovery sampleGenomes reference panelPrevious linkage studiesGWAS SNPsGWAS dataRelated traitsChromosomal regionsRisk lociRisk genesRisk variantsGenesReference panelAdditional genotypesLinkage studiesLociEuropean-American subjectsCocaine-induced paranoiaFAM53B