2016
DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders
Wang F, Xu H, Zhao H, Gelernter J, Zhang H. DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Scientific Reports 2016, 6: 19430. PMID: 26763658, PMCID: PMC4725922, DOI: 10.1038/srep19430.Peer-Reviewed Original ResearchConceptsCo-methylation modulesPostmortem prefrontal cortex tissueDNA methylome alterationsCo-methylation analysisDNA methylation alterationsSubstance dependence phenotypesTranscriptional regulationDNA methylomeMethylation alterationsMethylome alterationsBiological processesPostmortem prefrontal cortexExpression relationshipsNeural developmentDifferential expressionPrefrontal cortex tissueGenesDependence phenotypesMultiple testing correctionCpGAUD subjectsFemale pairsCortex tissueMethylomePhenotype
2013
Sex-biased methylome and transcriptome in human prefrontal cortex
Xu H, Wang F, Liu Y, Yu Y, Gelernter J, Zhang H. Sex-biased methylome and transcriptome in human prefrontal cortex. Human Molecular Genetics 2013, 23: 1260-1270. PMID: 24163133, PMCID: PMC3919013, DOI: 10.1093/hmg/ddt516.Peer-Reviewed Original ResearchConceptsDNA methylationGene expressionSex-biased DNA methylationMultiple test correctionGenome-wide DNA methylationGene Ontology annotationsDAVID functional annotation analysisFunctional annotation analysisRibosome structurePhenotypic variationAnnotation analysisGO termsProtein translationRNA bindingOntology annotationsHost genesDifferential methylationExpression correlationTranscriptomic profilesDifferential brain developmentDifferential expressionMethylation levelsGenesMethylationTranscriptome