Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter
KACZYNSKI J, CONLEY A, ZAPICO M, DELGADO S, ZHANG J, URRUTIA R. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Biochemical Journal 2002, 366: 873-882. PMID: 12036432, PMCID: PMC1222816, DOI: 10.1042/bj20020388.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, NorthernBlotting, WesternCarcinogensCell Cycle ProteinsCell LineCHO CellsChromatinCricetinaeCytochrome P-450 CYP1A1DNA, ComplementaryDNA-Binding ProteinsDose-Response Relationship, DrugGlutathione TransferaseHumansKruppel-Like Transcription FactorsMolecular Sequence DataPlasmidsPromoter Regions, GeneticProtein BindingProtein Structure, TertiaryRecombinant Fusion ProteinsRepressor ProteinsSequence Homology, Amino AcidSp1 Transcription FactorTrans-ActivatorsTranscription FactorsTranscription, GeneticZinc FingersConceptsGene promoterCYP1A1 gene promoterProtein familyC-terminal zinc-finger motifC-terminal zinc-finger domainBind GC-rich sequencesControl of gene expressionCo-repressor mSin3ASp1-like proteinsZinc-finger motifGC-rich sequencesFamily of proteinsN-terminal regionRepress transcriptionTranscriptional repressionCo-repressorTranscriptional repressorCellular machineryExpressed memberTranscriptional elementsTranscription factorsFunctional characterizationBTEB3Gene expressionTranscription