The Sp1-like Protein BTEB3 Inhibits Transcription via the Basic Transcription Element Box by Interacting with mSin3A and HDAC-1 Co-repressors and Competing with Sp1*
Kaczynski J, Zhang J, Ellenrieder V, Conley A, Duenes T, Kester H, van der Burg B, Urrutia R. The Sp1-like Protein BTEB3 Inhibits Transcription via the Basic Transcription Element Box by Interacting with mSin3A and HDAC-1 Co-repressors and Competing with Sp1*. Journal Of Biological Chemistry 2001, 276: 36749-36756. PMID: 11477107, DOI: 10.1074/jbc.m105831200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsBinding, CompetitiveBlotting, WesternCell Cycle ProteinsCHO CellsCricetinaeGenes, ReporterGlutathione TransferaseHistone Deacetylase 1Histone DeacetylasesKineticsKruppel-Like Transcription FactorsMolecular Sequence DataPlasmidsPrecipitin TestsPromoter Regions, GeneticProtein BindingProtein Structure, TertiaryRepressor ProteinsSin3 Histone Deacetylase and Corepressor ComplexSp1 Transcription FactorTrans-ActivatorsTranscription, GeneticZinc FingersConceptsCo-repressorN-terminusHDAC-1Bind GC-rich sequencesC-terminal zinc finger motifsGC-rich DNA elementsCo-repressor mSin3ASp1-like proteinsZinc finger motifsDNA-binding domainGC-rich sequencesSp1-like activityGel shift assaysMammalian cell homeostasisMechanism of repressionChinese hamster ovary cellsFinger motifDNA elementsSp1 familyRepressor domainRepressor proteinBTEB3GAL4 assayTranscriptional repressionTranscriptional repressor