Global Screening of Base Excision Repair in Nucleosome Core Particles
Sutton T, Sawyer D, Naila T, Sweasy J, Tomkinson A, Delaney S. Global Screening of Base Excision Repair in Nucleosome Core Particles. DNA Repair 2024, 103777. DOI: 10.1016/j.dnarep.2024.103777.Peer-Reviewed Original ResearchBase excision repairUracil-DNA glycosylaseAP endonuclease 1Nucleosome core particleBase excision repair enzymesAbsence of chromatin remodelingExcision repairDNA polymerase BGenome wide mappingContext of chromatinEukaryotic genomic DNADNA damageCore particlesPolymerase BChromatin remodelingActivities of BER enzymesNick siteGenomic DNAProtein interactionsMutational hotspotsNucleosomal DNADNA glycosylaseGenomic instabilityCellular factorsEntry/exit region