2021
Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding
Song SJ, Wang J, Martino C, Jiang L, Thompson WK, Shenhav L, McDonald D, Marotz C, Harris PR, Hernandez CD, Henderson N, Ackley E, Nardella D, Gillihan C, Montacuti V, Schweizer W, Jay M, Combellick J, Sun H, Garcia-Mantrana I, Gil Raga F, Collado MC, Rivera-Viñas JI, Campos-Rivera M, Ruiz-Calderon JF, Knight R, Dominguez-Bello MG. Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding. Med 2021, 2: 951-964.e5. PMID: 35590169, PMCID: PMC9123283, DOI: 10.1016/j.medj.2021.05.003.Peer-Reviewed Original ResearchConceptsMaternal vaginal fluidsCS birthBody sitesMaternal vaginal microbiomeVaginal fluidNon-pregnant womenDay of birthMultiple body sitesCesarean sectionImmunological underpinningsMicrobiota perturbationsClinical trialsVaginal seedingMicrobial exposureVaginal microbiomeMicrobiota developmentBabiesDisease riskBirthNational InstituteLongitudinal studyMaternal sitesPluripotential naturePublic healthFirst year
2018
Differences in the fecal microbiota of neonates born at home or in the hospital
Combellick JL, Shin H, Shin D, Cai Y, Hagan H, Lacher C, Lin DL, McCauley K, Lynch SV, Dominguez-Bello MG. Differences in the fecal microbiota of neonates born at home or in the hospital. Scientific Reports 2018, 8: 15660. PMID: 30353125, PMCID: PMC6199260, DOI: 10.1038/s41598-018-33995-7.Peer-Reviewed Original ResearchConceptsHospital-born infantsTime of birthPro-inflammatory gene expressionBreast fed neonatesInfants 1 monthLong-term health implicationsHuman colon epithelial HT-29 cellsDay of birthVaginal swab samplesMonths of ageLower BacteroidesMaternal antibioticsNeonate's microbiomeNeonatal microbiomeVaginal sourcesHT-29 cellsWater birthVaginal microbiotaIntestinal microbiotaDay 1Vaginal samplesHospitalInfantsFecal microbiotaBabies