2024
Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real?
Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.Peer-Reviewed Original Research
2021
Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis
Sanchez J, Jiao J, Kwan S, Veillon L, Warmoes M, Tan L, Odewole M, Rich N, Wei P, Lorenzi P, Singal A, Beretta L. Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis. Cancer Prevention Research 2021, 14: canprevres.0612.2021. PMID: 34253566, PMCID: PMC8546639, DOI: 10.1158/1940-6207.capr-20-0612.Peer-Reviewed Original ResearchConceptsLogistic regression analysisHCC exosomesCirrhotic patientsEarly detectionHepatocellular carcinomaCandidate biomarkersTumor developmentNoninvasive diagnostic biomarkersRegression analysisHCC surveillanceLipid profileEndocannabinoid signalingHCC diagnosisNovel biomarkersLipid classesDiagnostic biomarkersPlasma exosomesLipidomic profilesGlycerophospholipid metabolismHCCPatientsBiomarkersUntargeted lipidomicsCarcinomaDifferential effectsSomatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics
Jiao J, Sanchez J, Thompson E, Mao X, McCormick J, Fisher-Hoch S, Futreal P, Zhang J, Beretta L. Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics. International Journal Of Molecular Sciences 2021, 22: 7411. PMID: 34299031, PMCID: PMC8304329, DOI: 10.3390/ijms22147411.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisCell-free DNAHigher cfDNA concentrationsHepatocellular carcinomaLiver fibrosisCfDNA concentrationHCC patientsOverall survivalAdvanced fibrosisHCC risk predictionShorter overall survivalMajor risk factorNon-invasive markerPlasma cell-free DNADetectable mutationsSomatic mutationsCirculating Cell-Free DNARisk factorsHCC developmentCancer-associated genesDeath outcomesFibrosisPatientsNonsynonymous mutationsRisk predictionCirculating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids
2017
Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas
Jiao J, Niu W, Wang Y, Baggerly K, Ye Y, Wu X, Davenport D, Almeda J, Betancourt-Garcia M, Forse R, Stevenson H, Watt G, McCormick J, Fisher-Hoch S, Beretta L. Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Cancer Prevention Research 2017, 11: 103-112. PMID: 29089331, PMCID: PMC5811406, DOI: 10.1158/1940-6207.capr-17-0235.Peer-Reviewed Original ResearchConceptsAdvanced fibrosisHepatocellular carcinomaCell-free DNAHCC patientsHispanic subjectsShorter overall survivalPlasma cell-free DNAAsian HCC patientsOverall survivalWorse prognosisAflatoxin exposureHigh incidenceCirrhosisHCC tumorsPromising biomarkerDietary exposureFibrosisYounger agePatientsDroplet digital PCRHispanicsSomatic mutationsFamily membersUpstream regulatorSubjects