2023
Detection of Large-Droplet Macrovesicular Steatosis in Donor Livers Based on Segment-Anything Model
Tang H, Jiao J, Lin J, Zhang X, Sun N. Detection of Large-Droplet Macrovesicular Steatosis in Donor Livers Based on Segment-Anything Model. Laboratory Investigation 2023, 104: 100288. PMID: 37977550, DOI: 10.1016/j.labinv.2023.100288.Peer-Reviewed Original ResearchLiver diseaseMacrovesicular steatosisArtificial intelligence algorithmsArtificial intelligence modelsEnd-stage liver diseaseRule-based algorithmLiver histology analysisLiver transplant complicationsAcute liver failurePrimary hepatic malignancyLarge fat vacuolesIntelligence algorithmsDetection modelTransformer architectureIntelligence modelsTransplant complicationsLiver transplantationLiver failureLiver biopsyHepatic malignanciesFat vacuolesDonor organsEffective treatmentPrior knowledgeAlgorithmPostinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases
Jiao J, Chezar K, Zhang X, Wang D, Cao W, Bindu C, Chen W, Neto A, Henn P, Riahi I, Wang H, Papke D, Zhao L, Xue Y, Liao X, Zhang X. Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases. Modern Pathology 2023, 36: 100298. PMID: 37544363, DOI: 10.1016/j.modpat.2023.100298.Peer-Reviewed Original ResearchConceptsPostinfantile giant cell hepatitisAutoimmune liver diseaseGiant cell hepatitisAlkaline phosphatase levelsClinical outcomesPhosphatase levelsLiver diseaseMulti-institutional retrospective studyAssociated with better survivalAssociated with poor survivalClinicopathological characteristics of patientsAdverse prognostic factorAssociated with autoimmune liver diseasesGiant cellsVariable clinical outcomesFollow-up resultsCharacteristics of patientsDistribution of giant cellsOlder ageLiver disease etiologyPrognostic factorsAdvanced fibrosisBetter survivalClinicopathological characteristicsLiver allografts
2021
Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease
Kwan S, Jiao J, Joon A, Wei P, Petty L, Below J, Daniel C, Wu X, Zhang J, Jenq R, Futreal P, Hawk E, McCormick J, Fisher‐Hoch S, Beretta L. Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease. Hepatology 2021, 75: 955-967. PMID: 34633706, PMCID: PMC8930512, DOI: 10.1002/hep.32197.Peer-Reviewed Original ResearchConceptsLiver fibrosisMicrobiome signaturesHigh riskParabacteroides distasonisGut microbiomeCameron County Hispanic CohortEnrichment of PrevotellaGut microbiome signaturesVibration-controlled transient elastographyFatty liver diseaseHigh-risk populationPrevotella abundanceLiver diseaseProinflammatory environmentTransient elastographyPreventive strategiesBacteroides caccaeAlcohol consumptionFibrosisHispanic cohortDisease preventionProtein 2 geneFunctional changesNoninvasive meansB vitaminsCirculating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids
2020
Bile Acid Changes Associated With Liver Fibrosis and Steatosis in the Mexican‐American Population of South Texas
Kwan S, Jiao J, Qi J, Wang Y, Wei P, McCormick J, Fisher‐Hoch S, Beretta L. Bile Acid Changes Associated With Liver Fibrosis and Steatosis in the Mexican‐American Population of South Texas. Hepatology Communications 2020, 4: 555-568. PMID: 32258950, PMCID: PMC7109342, DOI: 10.1002/hep4.1490.Peer-Reviewed Original ResearchBile acid changesBile acid levelsNonalcoholic fatty liver diseaseFatty liver diseaseBile acid profilesLiver fibrosisLiver diseaseBile acidsAcid levelsHepatocellular carcinomaHigh-risk Mexican-American populationPrimary conjugated bile acidsUnconjugated secondary bile acidsTotal bile acid levelsCameron County Hispanic CohortGut microbiome contributesLithocholic acid levelsSignificant liver fibrosisSecondary bile acidsCommon risk factorsIndividual bile acidsEarly preventive interventionsConjugated bile acidsAcid changesAdvanced fibrosis
2018
Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis
Nguyen J, Jiao J, Smoot K, Watt G, Zhao C, Song X, Stevenson H, McCormick J, Fisher-Hoch S, Zhang J, Futreal P, Beretta L. Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. Oncotarget 2018, 9: 29495-29507. PMID: 30034633, PMCID: PMC6047684, DOI: 10.18632/oncotarget.25685.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseTLR4 mRNA expressionHepatocellular carcinomaMRNA expressionIL-6HCC patientsHCC developmentHCC tumorsIL-10 mRNA expressionToll-like receptor 4Fatty liver diseaseWhole-exome sequencingIngenuity Pathway AnalysisDistant liverIL-10Liver diseaseTLR4 inhibitorProinflammatory responseReceptor 4TLR4 activationHCC chemopreventionChemopreventionKey mediatorTumorsMiceDepletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
Jiao J, González Á, Stevenson H, Gagea M, Sugimoto H, Kalluri R, Beretta L. Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. Experimental & Molecular Medicine 2018, 50: e422-e422. PMID: 29303514, PMCID: PMC5992984, DOI: 10.1038/emm.2017.175.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell DifferentiationGene Expression Regulation, NeoplasticHepatitisHepatocytesLiver NeoplasmsLiver Neoplasms, ExperimentalMice, KnockoutMice, TransgenicNeoplastic Stem CellsNon-alcoholic Fatty Liver DiseasePTEN PhosphohydrolaseS100 Calcium-Binding Protein A4Stromal CellsConceptsDepletion of S100A4Hepatocellular carcinomaMouse modelCalcium-binding protein S100A4Stromal cellsStemness phenotypeDevelopment of HCCOval cell hyperplasiaReduction of inflammationStemness propertiesCell stemness propertiesNew mouse modelStem cell-like phenotypeViral thymidine kinaseCell-like phenotypeLiver diseaseCell hyperplasiaPoor prognosisGanciclovir injectionsNAS scoreAdjacent liverGastric cancerHCC developmentProtein S100A4Hepatic deletion