2016
Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD)
Fields M, Cai H, Gong J, Del Priore L. Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD). Cells 2016, 5: 44. PMID: 27941641, PMCID: PMC5187528, DOI: 10.3390/cells5040044.Peer-Reviewed Original ResearchInduced pluripotent stem cellsEmbryonic stem cellsAge-related macular degenerationPluripotent stem cellsCell replacement therapyDisease modelingIPSC disease modelingStem cellsReplacement therapyMacular degenerationRegenerative medicineRetinal pigment epithelium cellsStem cell biologyPigment epithelium cellsRetinal degenerative disordersUnlimited sourceDrug development platformClinical trialsDevelopment platformStargardt diseaseAnimal modelsRetinal degenerationAutologous sourceDegenerative disordersTherapeutic use
2015
Chapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cultures
Fields MA, Bowrey HE, Gong J, Ablonczy Z, Del Priore LV. Chapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cultures. Progress In Nucleic Acid Research And Molecular Biology 2015, 134: 477-490. PMID: 26310172, PMCID: PMC8680204, DOI: 10.1016/bs.pmbts.2015.06.004.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumRetinal degenerative diseasesAge-related macular degenerationDegenerative diseasesPluripotent stem cell (iPSC) technologyPromising clinical optionNative retinal pigment epitheliumRetinal degenerative disordersStem cell-derived retinal pigment epitheliumStem cell technologyVisual functionMacular degenerationPigment epitheliumRetinoid processingClinical optionDegenerative disordersClinical therapyCell therapyPluripotent stem cell-derived retinal pigment epitheliumVisual cycleRPE-specific proteinTherapyDiseaseStem cellsTrans retinol