Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageHumansHypertensionMinimally Invasive Surgical ProceduresRisk FactorsStrokeConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral Small Vessel DiseasesHematomaHumansLeukoaraiosisMagnetic Resonance ImagingConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2023
Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis
Roh DJ, Asonye IS, Poyraz F, Magid-Bernstein JR, Joiner EF, Avadhani R, Awad I, Hanley DF, Ziai WC, Murthy SB. Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis. Stroke 2022, 53: 1847-1853. PMID: 35086362, PMCID: PMC9133068, DOI: 10.1161/strokeaha.121.037438.Peer-Reviewed Original ResearchMeSH KeywordsAgedCerebral HemorrhageFemaleHematomaHumansMaleMiddle AgedRisk FactorsThalamusTomography, X-Ray ComputedConceptsCLEAR III trialVentriculoperitoneal shunt placementIntraventricular hemorrhage expansionIII trialsIVH patientsShunt placementICH locationHematoma expansionIVH expansionHemorrhage expansionSubsequent ventriculoperitoneal shunt placementGlasgow Coma Scale scoreBaseline ICH volumeClinical trial cohortComposite of deathLong-term outcomesMultivariable logistic regressionPoor functional outcomePost-hoc exploratory analysisMultivariable regression modelsIntracerebral hemorrhage volumeRandomization armAnticoagulant useTrial cohortClinical outcomes
2020
Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage
Roh DJ, Carvalho Poyraz F, Magid-Bernstein J, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Hod E, Murthy SB. Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105317. PMID: 32992186, PMCID: PMC7686150, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105317.Peer-Reviewed Original ResearchConceptsRBC transfusionICH outcomeDisease severityComorbidity burdenICH hospitalizationsPoor outcomeRed blood cell transfusionICD-9-CM codesBlood cell transfusionAdditional prospective studiesRed blood cell levelsIntracerebral hemorrhage outcomesNationwide Inpatient SampleLower red blood cell levelsBlood cell levelsBaseline comorbiditiesHospital mortalityTransfusion exposureVentriculostomy drainsCell transfusionLow comorbidityIntracerebral hemorrhageMechanical ventilationProspective studyInpatient Sample
2019
Low hemoglobin and hematoma expansion after intracerebral hemorrhage.
Roh DJ, Albers DJ, Magid-Bernstein J, Doyle K, Hod E, Eisenberger A, Murthy S, Witsch J, Park S, Agarwal S, Connolly ES, Elkind MSV, Claassen J. Low hemoglobin and hematoma expansion after intracerebral hemorrhage. Neurology 2019, 93: e372-e380. PMID: 31209179, PMCID: PMC6669932, DOI: 10.1212/wnl.0000000000007820.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsLower admission hemoglobin levelsLower hemoglobin levelsHemoglobin levelsHematoma expansionLower hemoglobinWorse outcomesMultivariable logistic regression modelSeparate multivariable logistic regression modelsPoor clinical outcomeMeeting inclusion criteriaIntracerebral hemorrhage volumeLogistic regression modelsAdmission hemoglobinRankin ScaleCohort studyConsecutive patientsClinical outcomesIntracerebral hemorrhagePoor outcomeICH outcomeICH scoreHemorrhage volumeModifiable targetsInclusion criteria