2019
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation
Xiang Q, Yang B, Li L, Qiu B, Qiu C, Gao X, Zhou H, Min W. Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation. Journal Of Cellular And Molecular Medicine 2019, 23: 0-0. PMID: 30734494, PMCID: PMC6433861, DOI: 10.1111/jcmm.14202.Peer-Reviewed Original ResearchConceptsCardiac stem cell activationStem cell activationHuman inducible pluripotent stem cellsCardiac stem cell differentiationCSC activationStem cell differentiationInducible pluripotent stem cellsPluripotent stem cellsCardiac progenitor cellsCritical roleActivation of TNFR2Factor RNACell activationProtein Lin28Cardiomyocyte proteinsCell differentiationStem cellsProgenitor cellsStem cell-based therapiesCSC differentiationProtein expressionDifferentiationCell-based therapiesExpressionActivation
2017
Mechanistic Role of Thioredoxin 2 in Heart Failure
Chen C, Chen H, Zhou HJ, Ji W, Min W. Mechanistic Role of Thioredoxin 2 in Heart Failure. Advances In Experimental Medicine And Biology 2017, 982: 265-276. PMID: 28551792, DOI: 10.1007/978-3-319-55330-6_14.Peer-Reviewed Original ResearchConceptsThioredoxin 2ASK1-dependent apoptosisMechanistic roleMitochondrial reactive oxygen species generationCellular oxidative stressGlobal gene knockoutMitochondrial proteinsEmbryonic lethalityMitochondrial Trx2Gene knockoutKinase 1Reactive oxygen species generationTrx2Key mechanistic roleOxygen species generationCardiomyocyte apoptosisActive tissuesApoptosisCommon mechanismOxidative stressSpecies generationPromising targetHeart failureTherapeutic strategiesTreatment of DCM