2014
Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model
Yang L, Xu Y, Li W, Yang B, Yu S, Zhou H, Yang C, Xu F, Wang J, Gao Y, Huang Y, Lu L, Liang X. Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model. Journal Of Molecular Neuroscience 2014, 56: 78-88. PMID: 25451596, DOI: 10.1007/s12031-014-0469-2.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorVascular endothelial growth factorRetinal neovascularizationRetinopathy modelHIF-1α/VEGF pathwayOxygen-induced retinopathy modelExposure of hyperoxiaSuppress retinal neovascularizationPostnatal day 7Endothelial growth factorProlyl hydroxylasesOIR miceOIR modelRetinal astrocytesIntraperitoneal injectionPathologic neovascularizationVEGF pathwayDay 7Astrocyte morphologyHIF-1αNeovascularizationPHD-2Room airHIF-α subunitsGrowth factor
2012
TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy
Liang X, Zhou H, Ding Y, Li J, Yang C, Luo Y, Li S, Sun G, Liao X, Min W. TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2012, 53: 2157-2169. PMID: 22410554, PMCID: PMC4627509, DOI: 10.1167/iovs.11-9315.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisDisease Models, AnimalDrugs, Chinese HerbalFluorescent Antibody Technique, IndirectGlial Fibrillary Acidic ProteinHypoxia-Inducible Factor 1, alpha SubunitIn Situ Nick-End LabelingLigusticumMiceMice, Inbred C57BLMicroscopy, ConfocalNerve Tissue ProteinsNeuroprotective AgentsOxygenPyrazinesReperfusion InjuryRetinal NeovascularizationRetinal NeuronsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVascular Endothelial Growth Factor AVasodilator AgentsConceptsEffects of tetramethylpyrazineVEGF mRNA expressionCell bodiesRetinal neovascularizationAvascular retinaMüller cellsMouse retinaHIF-1αMRNA expressionOxygen-induced retinopathy modelIschemia-induced cell deathHorizontal cell bodiesNeonatal C57BL/6J miceOuter plexiform layerPostnatal day 7Amacrine cell bodiesTUNEL-positive cellsMüller cell bodiesImparts NeuroprotectionNeurovascular recoveryNeurovascular repairControl miceC57BL/6J micePlexiform layerNormal saline
2011
Retro-orbital injection of FITC-dextran is an effective and economical method for observing mouse retinal vessels.
Li S, Li T, Luo Y, Yu H, Sun Y, Zhou H, Liang X, Huang J, Tang S. Retro-orbital injection of FITC-dextran is an effective and economical method for observing mouse retinal vessels. Molecular Vision 2011, 17: 3566-73. PMID: 22219652, PMCID: PMC3250377.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornDextransFluorescein AngiographyFluorescein-5-isothiocyanateHeart VentriclesHumansImage Processing, Computer-AssistedInfant, NewbornInjections, IntraocularMiceMice, Inbred C57BLMolecular ImagingOxygenPerfusionRetinaRetinal VesselsRetinopathy of PrematurityReverse Transcriptase Polymerase Chain ReactionSoftwareConceptsMouse retinal vesselsRO injectionOIR miceOxygen-induced retinopathyRetro-orbital injectionLV perfusionRetinal vesselsFITC-dextranTotal retina areaArea of neovascularizationRetinal flatmountsRetinal neovascularizationVentricular perfusionNormal miceFluorescein isothiocyanate-dextranRetina areaLeft ventriclePostnatal micePerfusionMiceOrbital injectionInjectionSignificant differencesNeovascularizationVessels