2017
An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review
Ross DA, Arbuckle MR, Travis MJ, Dwyer JB, van Schalkwyk GI, Ressler KJ. An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review. JAMA Psychiatry 2017, 74: 407-415. PMID: 28273291, PMCID: PMC5504531, DOI: 10.1001/jamapsychiatry.2016.3325.Peer-Reviewed Original ResearchMeSH KeywordsAfghan Campaign 2001-AnimalsBrainCombat DisordersConditioning, ClassicalDisease Models, AnimalEpigenesis, GeneticFearHumansHypothalamo-Hypophyseal SystemIraq War, 2003-2011Memory ConsolidationMilitary PersonnelNerve NetNeurosciencesPatient Care PlanningPituitary-Adrenal SystemStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderNeuroscience perspectiveMemory reconsolidationStress disorderCase formulationTreatment of PTSDNeuroscience-informed approachBasic learning theoryAberrant network connectivityModern neuroscience perspectiveFear conditioningRange of behaviorsTraumatic eventsPrefrontal cortexIndividual's abilityLearning theoryReconsolidationSpecific experiencesNeuroscienceCommon psychiatric illnessLimbic structuresSocial perspectiveConditioningNetwork connectivityLong-term effects
2016
Modern Microglia: Novel Targets in Psychiatric Neuroscience
Dwyer JB, Ross DA. Modern Microglia: Novel Targets in Psychiatric Neuroscience. Biological Psychiatry 2016, 80: e47-e49. PMID: 27601341, PMCID: PMC5371712, DOI: 10.1016/j.biopsych.2016.08.006.Peer-Reviewed Original ResearchAdolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents
Dwyer JB, Leslie FM. Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents. PLOS ONE 2016, 11: e0146966. PMID: 26784516, PMCID: PMC4718668, DOI: 10.1371/journal.pone.0146966.Peer-Reviewed Original ResearchConceptsD1/D2 interactionsImmediate early genesIEG expressionD2 receptor functionCommon neurobiological substrateMesocorticolimbic dopamine systemDopamine receptor bindingStress-related circuitryIllicit drug useFunctional neural circuitryAge-dependent changesDrugs of abuseD2 agonistDopamine D1Bed nucleusStria terminalisAdult ratsPharmacological actionsDopamine systemDrug useLow dosesBNST functionDirect D1Neuropsychiatric disordersReceptor function
2011
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats
Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD. Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. The International Journal Of Neuropsychopharmacology 2011, 14: 157-174. PMID: 20196919, PMCID: PMC5575906, DOI: 10.1017/s1461145710000179.Peer-Reviewed Original ResearchConceptsGestational nicotine treatmentLimbic brain regionsCell adhesion moleculePsychiatric disordersBrain regionsPregnant Sprague-Dawley ratsGestational day 4Prenatal nicotine exposureNicotine replacement therapyPostnatal day 35Sprague-Dawley ratsMajor psychoactive componentAdolescent female ratsCentral nervous systemQuantitative RT-PCR techniqueRT-PCR techniqueMaternal smokingNicotine treatmentNicotine exposureReplacement therapyCaudate putamenFemale ratsPrenatal treatmentNeurotransmitter systemsNeurobehavioural deficits
2009
The dynamic effects of nicotine on the developing brain
Dwyer JB, McQuown SC, Leslie FM. The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics 2009, 122: 125-139. PMID: 19268688, PMCID: PMC2746456, DOI: 10.1016/j.pharmthera.2009.02.003.Peer-Reviewed Original ResearchConceptsNicotine exposureDevelopmental influencesAdolescent periodBrain maturationExogenous nicotineHuman brainUnique effectsMaturational periodNeural structuresLimbic systemClinical literatureNicotine replacement therapyEnvironmental stimuliEarly postnatal periodPreclinical animal modelsDevelopmental windowNicotinic acetylcholine receptorsPrenatal periodReplacement therapyEarly postnatalPostnatal periodTobacco smokeAnimal modelsAcetylcholine receptorsNicotine
2008
Nicotine and brain development
Dwyer JB, Broide RS, Leslie FM. Nicotine and brain development. Birth Defects Research Part C Embryo Today Reviews 2008, 84: 30-44. PMID: 18383130, DOI: 10.1002/bdrc.20118.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyMaternal smokingPharmacologic propertiesBrain developmentSudden infant death syndromeFetal central nervous systemAuditory cognitive dysfunctionActivation of nAChRsInfant death syndromeCentral nervous systemNumerous brain regionsNicotinic acetylcholine receptorsCell survivalLigand-gated ion channelsLong-term alterationsSpecific neural circuitryCritical developmental periodPregnant womenReplacement therapyTobacco cessationCholinergic modulationFunctional statusNeonatal brainPreclinical studiesTransmitter release