2022
Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88.
Soldatenko A, Hoyt LR, Xu L, Calabro S, Lewis SM, Gallman AE, Hudson KE, Stowell SR, Luckey CJ, Zimring JC, Liu D, Santhanakrishnan M, Hendrickson JE, Eisenbarth SC. Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. The Journal Of Immunology 2022, 208: 991-997. PMID: 35039331, PMCID: PMC10107373, DOI: 10.4049/jimmunol.2100784.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsDendritic cellsDC activationAdaptive immunityClass of PRRsNon-ABO alloantibodiesRecipient dendritic cellsSplenic dendritic cellsMouse RBCsInflammatory cytokine responseTreatment of anemiaRBC transfusion therapyTransfused RBCsAlloantibody responsesAllogeneic RBCsSerious complicationsCytokine responsesTransfusion therapyRecognition receptorsMyD88TransfusionAlloimmunizationRBCsTRIFUnknown mechanism
2013
Storage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age
Arthur C, Smith N, Zimring J, Hendrickson J, Stowell S. Storage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age. Blood 2013, 122: 792. DOI: 10.1182/blood.v122.21.792.792.Peer-Reviewed Original ResearchOld RBCsPost transfusionPositive RBCsEnhanced clearanceRBC ageCytometric analysisPreferential clearanceCitrate phosphate dextrose adenineDays post transfusionPercent of RBCsRBC removalRed blood cell storageClearance of RBCsFlow cytometric analysisTransfused RBCsB6 miceDonor RBCsTransfusionSenescent markersRBC clearanceGradual clearanceClearance phaseRapid clearanceClearanceStored RBCs