2021
Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice
Escamilla-Rivera V, Santhanakrishnan M, Liu J, Gibb DR, Forsmo JE, Foxman EF, Eisenbarth SC, Luckey CJ, Zimring JC, Hudson KE, Stowell SR, Hendrickson JE. Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. Frontiers In Immunology 2021, 12: 704072. PMID: 34249009, PMCID: PMC8270673, DOI: 10.3389/fimmu.2021.704072.Peer-Reviewed Original ResearchConceptsImmunoprophylaxis failureRed blood cellsRBC transfusionComplement receptorsHuman KEL glycoproteinB cell activation thresholdWild-type micePresence of complementMurine red blood cellsTwo-hit modelRecipient inflammationIgG alloantibodiesInflammatory monocytesAdaptive immunityType miceB cellsRecipient complementTranslational relevanceKey cellsTransfusionMiceBlood cellsImmunoprophylaxis efficacyBaseline stateActivation threshold
2020
Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice
Escamilla-Rivera V, Liu J, Gibb DR, Santhanakrishnan M, Liu D, Forsmo JE, Eisenbarth S, Foxman EF, Stowell SR, Luckey CJ, Zimring JC, Hudson KE, Hendrickson J. Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. Blood 2020, 135: 1983-1993. PMID: 32266378, PMCID: PMC7256361, DOI: 10.1182/blood.2020005018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCytokinesDisease Models, AnimalErythroblastosis, FetalErythrocyte TransfusionErythrocytesFemaleHumansImmunization, PassiveInterferon Type IIsoantigensKell Blood-Group SystemMembrane GlycoproteinsMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhagocytosisPoly I-CPregnancyConceptsRed blood cellsSerum monocyte chemoattractant protein-1Monocyte chemoattractant protein-1Blood cellsHuman KEL glycoproteinPolyinosinic-polycytidilic acidTransfused red blood cellsType 1 IFNType I IFN receptorChemoattractant protein-1Type 1 interferonI IFN receptorMurine red blood cellsRecipient CD4Recipient inflammationIFN administrationSerum cytokinesInflammatory monocytesRecipient treatmentInterleukin-6Hemolytic diseaseT cellsMurine modelAlloimmunizationKnockout mice
2018
3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice
Madrid D, Gibb D, Natarajan P, Santhanakrishnan M, Liu J, Hendrickson J. 3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice. American Journal Of Clinical Pathology 2018, 149: s164-s164. DOI: 10.1093/ajcp/aqx149.372.Peer-Reviewed Original ResearchCD40/CD40 ligand interactionsCD40 ligand interactionsCD40/CD40L blockadeWild-type animalsRed blood cellsNonresponder animalsCD40L blockadeWeeks posttransfusionType animalsIgG antibodiesT cellsImmune responseMonoclonal antibodiesAbsence of CD4CD40 ligand blockadeHuman KEL glycoproteinFlow cytometric crossmatchHemolytic transfusion reactionsDurable immune responsesHumoral immune responseWild-type miceDevelopment of alloantibodiesT cell interactionsMurine red blood cellsAlloantibody responses
2013
Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models
Hendrickson J. Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models. Blood 2013, 122: sci-49. DOI: 10.1182/blood.v122.21.sci-49.sci-49.Peer-Reviewed Original ResearchRed blood cellsMurine red blood cellsPreventive therapyRBC alloantibodiesTransfusion settingsRBC precursorsHemolytic diseaseAnimal modelsAntigen-negative red blood cellsNewborn pupsRed blood cell alloimmunizationPositive indirect antiglobulin testBone marrow erythroid precursorsMature red blood cellsFetal liverNegative red blood cellsPotential preventive therapyRBC-specific expressionRh immune globulinFlow cytometric crossmatchPregnancy/deliveryFetus/neonateForeign red blood cellsWeeks of deliveryIndirect antiglobulin test
2010
Fresh Murine Red Blood Cells Abrogate the Enhanced Alloimmunogenicity of Stored Murine Red Blood Cells
Hendrickson J, Hod E, Spitalnik S, Zimring J. Fresh Murine Red Blood Cells Abrogate the Enhanced Alloimmunogenicity of Stored Murine Red Blood Cells. Blood 2010, 116: 663. DOI: 10.1182/blood.v116.21.663.663.Peer-Reviewed Original ResearchFresh red blood cellsStored red blood cellsMurine red blood cellsRed blood cellsOld red blood cellsBlood cellsMurine modelFlow cytometric crossmatchRandomized clinical studyRates of immunizationYoung red blood cellsAdditional control animalsCPDA-1Alloimmunization rateFVB controlsAlloantibody responsesAlloimmune responseC57BL/6 recipientsCytometric crossmatchPotential deleterious effectsImmunoregulatory propertiesWorse outcomesClinical dataClinical studiesAntigen expression