2020
Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex
Werling DM, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santpere G, Sousa AMM, Tebbenkamp ATN, Kaur N, Gulden FO, Breen MS, Liang L, Gilson MC, Zhao X, Dong S, Klei L, Cicek AE, Buxbaum JD, Adle-Biassette H, Thomas JL, Aldinger KA, O’Day D, Glass IA, Zaitlen NA, Talkowski ME, Roeder K, State MW, Devlin B, Sanders SJ, Sestan N. Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex. Cell Reports 2020, 31: 107489. PMID: 32268104, PMCID: PMC7295160, DOI: 10.1016/j.celrep.2020.03.053.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBrainComputational BiologyDatabases, GeneticExome SequencingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenomicsHumansPhenotypePolymorphism, Single NucleotidePrefrontal CortexQuantitative Trait LociSequence Analysis, RNATranscriptomeWhole Genome SequencingConceptsExpression levelsGene expression levelsTranscriptomic coordinationDisorder lociNeuropsychiatric traitsSpecific genesRisk lociGene expressionGenomic variantsDevelopmental stagesCell typesGenesLociTissue RNACommon variantsPostnatal stagesUnique resourceSpecific variantsExpressionEQTLsVariantsGenomeHuman prefrontal cortexRNATraits
2018
The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages
Yosef N, Vadakkan TJ, Park JH, Poché RA, Thomas JL, Dickinson ME. The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages. Developmental Biology 2018, 442: 138-154. PMID: 30016639, PMCID: PMC6190604, DOI: 10.1016/j.ydbio.2018.07.009.Peer-Reviewed Original ResearchConceptsEmbryonic macrophagesErythro-myeloid progenitorsNeural stem/progenitor cellsExtra-embryonic yolk sacMouse neural stem/progenitor cellsEndothelial cell cord formationStem/progenitor cellsNon-immune functionsEC tube formationDevelopmental processesPrimitive erythroblastsTissue-resident populationsCord formationEarly cellsDirect cellKey inducerProgenitor cellsYolk sacCell contactEssential roleTube formationSpecialized propertiesBone marrowCell maturationProgenitors
2014
Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature
Hallani S, Colin C, Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M. Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature. BioMed Research International 2014, 2014: 827327. PMID: 24868550, PMCID: PMC4017715, DOI: 10.1155/2014/827327.Peer-Reviewed Original ResearchAntigens, CDBrain NeoplasmsCadherinsCell DifferentiationCell ProliferationCoculture TechniquesEndoglinEndothelial CellsErbB ReceptorsGene Expression Regulation, NeoplasticGlioblastomaGreen Fluorescent ProteinsHuman Umbilical Vein Endothelial CellsHumansIn Situ Hybridization, FluorescenceLentivirusMicrocirculationNeoplasmsNeovascularization, PathologicPhenotypePlatelet Endothelial Cell Adhesion Molecule-1Receptors, Cell Surface
2012
Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation
Bouvrée K, Brunet I, del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A. Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation. Circulation Research 2012, 111: 437-445. PMID: 22723296, PMCID: PMC3861899, DOI: 10.1161/circresaha.112.269316.Peer-Reviewed Original ResearchAnimalsAnimals, NewbornAntibodies, NeutralizingBacterial ProteinsCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalGenotypeGestational AgeHumansLuminescent ProteinsLymphatic VesselsMiceMice, KnockoutMice, TransgenicMorphogenesisNerve Tissue ProteinsNeuropilin-1PhenotypeReceptors, Cell SurfaceRNA, MessengerSemaphorin-3AVascular Endothelial Growth Factor Receptor-3