2013
Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non‐Native Aromatic Products
Vagstad AL, Newman AG, Storm PA, Belecki K, Crawford JM, Townsend CA. Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non‐Native Aromatic Products. Angewandte Chemie International Edition 2013, 52: 1718-1721. PMID: 23283670, PMCID: PMC3810244, DOI: 10.1002/anie.201208550.Peer-Reviewed Original Research
2011
Bacterial symbionts and natural products
Crawford JM, Clardy J. Bacterial symbionts and natural products. Chemical Communications 2011, 47: 7559-7566. PMID: 21594283, PMCID: PMC3174269, DOI: 10.1039/c1cc11574j.Peer-Reviewed Original Research
2010
New insights into the formation of fungal aromatic polyketides
Crawford JM, Townsend CA. New insights into the formation of fungal aromatic polyketides. Nature Reviews Microbiology 2010, 8: 879-889. PMID: 21079635, PMCID: PMC3181163, DOI: 10.1038/nrmicro2465.Peer-Reviewed Original ResearchConceptsAromatic polyketide biosynthesisPolyketide synthasesStarter unitAromatic polyketidesNR-PKSsAcyl carrier protein domainIterative polyketide synthasesProduct template (PT) domainsAcyl-CoA poolSingle genomeProduct releaseKetosynthase domainCorrect substrateProtein domainsSubsequent product releaseBiosynthesis systemTemplate domainFilamentous fungiUnknown functionEnzyme structureDiverse familySynthesis pathwayKey cyclizationCyclization patternsPolyketides
2008
Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect”
Crawford JM, Vagstad AL, Whitworth KP, Ehrlich KC, Townsend CA. Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect”. ChemBioChem 2008, 9: 1019-1023. PMID: 18338425, PMCID: PMC3182100, DOI: 10.1002/cbic.200700702.Peer-Reviewed Original Research
2006
New Images Evoke FAScinating Questions
Townsend CA, Crawford JM, Bililign T. New Images Evoke FAScinating Questions. Cell Chemical Biology 2006, 13: 349-351. PMID: 16632247, DOI: 10.1016/j.chembiol.2006.04.001.Peer-Reviewed Original Research