2017
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis
Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/mcg.0000000000000591.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlanine TransaminaseAlkaline PhosphataseBile Acids and SaltsCholagogues and CholereticsCholangitis, SclerosingCholestenonesDrug Therapy, CombinationFemaleHumansLiverLiver Function TestsMaleMiddle AgedPilot ProjectsTreatment OutcomeTretinoinUrsodeoxycholic AcidYoung AdultConceptsPrimary sclerosing cholangitisUrsodeoxycholic acidAlanine aminotransferaseUDCA monotherapyPrimary endpointSclerosing cholangitisMedian serum alanine aminotransferasePilot studyWeeks of therapyMarkers of inflammationSerum alanine aminotransferaseRetinoic acidAlkaline phosphataseAll-Trans Retinoic AcidSerum ALP levelsHuman pilot studyCombination of ATRAAddition of ATRABile acid synthesisTrans retinoic acidExploratory pilot studyALT levelsAccepted therapyWeek 12C4 levels
1982
Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1
Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.Peer-Reviewed Original ResearchConceptsBile acid excretionAcid excretionEffect of chlorpromazineBile acidsRat liverRat liver 1Glutamic oxalacetic transaminase activityHepatic perfusionHepatic functionTransaminase releasePerfusate concentrationPerfusate flowConstant infusionDrug AdministrationBile acid extractionControl liversHepatic clearanceGlutamic pyruvicTransaminase activityExcretionSodium taurocholateLiver 1Eventual excretionLiverChlorpromazine
1980
Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease
Schneider J, Baker A, Haines N, Hatfield G, Boyer J. Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease. Gastroenterology 1980, 79: 1145-1150. PMID: 6777231, DOI: 10.1016/0016-5085(80)90906-3.Peer-Reviewed Original ResearchConceptsAminopyrine breath testAlcoholic liver diseaseBreath testLiver diseaseAlcoholic hepatitisClinical improvementHistologic severityLiver functionConventional liver function testsLiver function testsGroup of patientsShort-term survivalClinical featuresFunction testsHistologic confirmationClinical statusProthrombin timePatientsPrognostic testDiseaseHepatitisSeveritySurvivalSGPTSGOT