2001
Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
Soroka C, Lee J, Azzaroli F, Boyer J. Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 2001, 33: 783-791. PMID: 11283840, DOI: 10.1053/jhep.2001.23501.Peer-Reviewed Original ResearchConceptsObstructive cholestasisMultidrug resistance-associated protein 3Bile duct-ligated animalsMultidrug resistanceToxic bile acidsModel of cholestasisDuct-ligated animalsExpression of MRP3Intensity of stainingHepatocytes of liverWestern blot analysisBile ductHepatic expressionCentral veinCholestasisMRP3 expressionNormal liverBile acidsPericentral regionsIndirect immunofluorescenceProtein 3Days postligationMRP3Mrp2 proteinLiver
1996
Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis
Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka C, Stolz A, Suchy F, Boyer J. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996, 110: 199-209. PMID: 8536857, DOI: 10.1053/gast.1996.v110.pm8536857.Peer-Reviewed Original ResearchMeSH Keywords3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)3-Hydroxysteroid DehydrogenasesAnimalsCarrier ProteinsCholestasis, ExtrahepaticCommon Bile DuctDown-RegulationHomeostasisLigationLiverMaleOrganic Anion Transporters, Sodium-DependentProteinsRatsRats, Sprague-DawleyRNA, MessengerSymportersTaurocholic AcidTissue DistributionTranscription, GeneticConceptsEcto-adenosine triphosphataseRegulation of expressionMolecular regulationPosttranscriptional regulationGene transcriptionSteady-state messenger RNA levelsTranscriptional activityAcid transportersProtective feedback mechanismComplementary DNAAcid cotransporterMessenger RNA levelsSodium-dependent taurocholateTranscriptionRNA levelsRegulationBile acid transporterMRNA levelsHepatic bile acid transportersCanalicular localizationTaurocholate uptakeAlpha-hydroxysteroid dehydrogenaseExpressionNtcp proteinTriphosphatase