Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer
Ha Y, Chihara Y, Yoon H, Kim Y, Kim T, Woo S, Yun S, Kim I, Hirao Y, Kim W. Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer. Urologia Internationalis 2012, 90: 233-239. PMID: 23295344, DOI: 10.1159/000345608.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Renal CellFemaleFumarate HydrataseGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticGerm-Line MutationHumansKidneyKidney NeoplasmsMaleMiddle AgedRNA, MessengerTime FactorsYoung AdultConceptsKidney tissueRenal cell cancer syndromeFumarate hydrataseSporadic renal cell cancerMRNA levelsRenal cell cancerNormal renal parenchymaSporadic RCCReal-time quantitative polymerase chain reactionQuantitative polymerase chain reactionClinical characteristicsCell cancerPolymerase chain reactionRenal parenchymaHereditary leiomyomatosisClinical significanceImmunohistochemical stainingPrimary RCCTumor specimensRCC tissuesCancer syndromesClinical implicationsTumor tissueMRNA expressionGermline mutations