2000
Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)‐TGF‐β type II dominant negative receptor
Kundu S, Kim I, Yang T, Doglio L, Lang S, Zhang X, Buttyan R, Kim S, Chang J, Cai X, Wang Z, Lee C. Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)‐TGF‐β type II dominant negative receptor. The Prostate 2000, 43: 118-124. PMID: 10754527, DOI: 10.1002/(sici)1097-0045(20000501)43:2<118::aid-pros6>3.0.co;2-v.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IAnimalsApoptosisGenes, DominantGenomeImmunohistochemistryMaleMiceMice, TransgenicOrgan SizePromoter Regions, GeneticProstateProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, AndrogenReceptors, Transforming Growth Factor betaTestosteroneConceptsVentral prostateEpithelial cellsAnimal prostatesDominant negative receptorTransgenic miceNegative receptorProstate-specific promotersProstatic epithelial cellsTransgenic mouse systemTGF-beta resultsSerum levelsTGF-beta signalingProstate growthProstatic growthNormal prostateAndrogenic statusProstateProximal ductExperimental modelLoss of apoptosisInhibitory effectMouse systemSignificant differencesAbnormal morphologyLoss of sensitivity
1998
ABSENCE OF EXPRESSION OF TRANSFORMING GROWTH FACTOR-beta TYPE II RECEPTOR IS ASSOCIATED WITH AN AGGRESSIVE GROWTH PATTERN IN A MURINE RENAL CARCINOMA CELL LINE, RENCA
KUNDU S, KIM I, ZELNER D, JANULIS L, GOODWIN S, ENGEL J, LEE C. ABSENCE OF EXPRESSION OF TRANSFORMING GROWTH FACTOR-beta TYPE II RECEPTOR IS ASSOCIATED WITH AN AGGRESSIVE GROWTH PATTERN IN A MURINE RENAL CARCINOMA CELL LINE, RENCA. Journal Of Urology 1998, 160: 1883-1888. PMID: 9783979, DOI: 10.1016/s0022-5347(01)62437-6.Peer-Reviewed Original ResearchConceptsTGF-beta1 productionRenca cellsTGF-beta sensitivityRenal carcinoma cell linesCarcinoma cell linesInhibitory effectEndogenous TGF-beta1 productionWild-type Renca cellsCell linesTGF-beta receptor expressionTbetaR-II mRNAAggressive growth patternGrowth factor beta type II receptorTGF-beta1 mRNATGF-beta insensitivityPlasminogen activator inhibitorTbetaR-I mRNAType II receptorAbsence of expressionReceptor expressionTbetaR-IIII receptorsActivator inhibitorAggressive growthThymidine incorporationABSENCE OF EXPRESSION OF TRANSFORMING GROWTH FACTOR-beta TYPE II RECEPTOR IS ASSOCIATED WITH AN AGGRESSIVE GROWTH PATTERN IN A MURINE RENAL CARCINOMA CELL LINE, RENCA
KUNDU S, KIM I, ZELNER D, JANULIS L, GOODWIN S, ENGEL J, LEE C. ABSENCE OF EXPRESSION OF TRANSFORMING GROWTH FACTOR-beta TYPE II RECEPTOR IS ASSOCIATED WITH AN AGGRESSIVE GROWTH PATTERN IN A MURINE RENAL CARCINOMA CELL LINE, RENCA. Journal Of Urology 1998, 160: 1883-1888.. DOI: 10.1097/00005392-199811000-00077.Peer-Reviewed Original ResearchT beta RRenca cellsTGF-beta sensitivityRenal carcinoma cell linesCarcinoma cell linesBeta RInhibitory effectWild-type Renca cellsCell linesTGF-beta receptor expressionAggressive growth patternGrowth factor beta type II receptorTGF-beta insensitivityPlasminogen activator inhibitorType II receptorAbsence of expressionReceptor expressionII receptorsActivator inhibitorAggressive growthTumor cellsThymidine incorporationRT-PCRCancer cellsReceptors
1996
Modulation of Sensitivity to Transforming Growth Factor-β1 (TGF-β1) and the Level of Type II TGF-β Receptor in LNCaP Cells by Dihydrotestosterone
Kim I, Zelner D, Sensibar J, Ahn H, Park L, Kim J, Lee C. Modulation of Sensitivity to Transforming Growth Factor-β1 (TGF-β1) and the Level of Type II TGF-β Receptor in LNCaP Cells by Dihydrotestosterone. Experimental Cell Research 1996, 222: 103-110. PMID: 8549651, DOI: 10.1006/excr.1996.0013.Peer-Reviewed Original ResearchMeSH KeywordsBinding, CompetitiveCell CountCell DivisionDihydrotestosteroneDNA, NeoplasmHumansMalePromoter Regions, GeneticProstatic NeoplasmsProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaTranscriptional ActivationTransforming Growth Factor betaTumor Cells, CulturedConceptsTGF-beta receptor type IILNCaP cellsReceptor type IIAndrogen-responsive prostate cancerCharcoal-stripped fetal bovine serumEffect of dihydrotestosteroneGrowth factor-β1Type II TGF-β receptorProstate cancer cellsGrowth inhibitory effectsTGF-β receptorWestern blot analysisDHT concentrationsPresent studyType IIModulation of sensitivityProstate cancerAndrogenic conditionsFactor-β1DihydrotestosteronePotential physiological regulatorsInhibitory effectGene transcriptional activityCancer cellsPhysiological regulator