1998
Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1
Rohlff C, Blagosklonny M, Kyle E, Kesari A, Kim I, Zelner D, Hakim F, Trepel J, Bergan R. Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1. The Prostate 1998, 37: 51-59. PMID: 9721069, DOI: 10.1002/(sici)1097-0045(19980915)37:1<51::aid-pros8>3.0.co;2-b.Peer-Reviewed Original ResearchConceptsProstate cancer cell growthCancer cell growthProtein kinase CHormone-refractory prostate cancerProstate cancer cell growth inhibitionGrowth inhibitionInhibition of PKCG1/S phase cell cycle arrestTamoxifen-mediated growth inhibitionCancer cell growth inhibitionProstate cancer cellsPhase cell cycle arrestDU145 prostate cancer cellsS-phase cell cycle arrestRetinoblastoma protein levelsFlow cytometric analysisP21WAF1/CIP1Cell growth inhibitionTamoxifen treatmentCell cycle arrestCell growthProstate cancerKinase CCytometric analysisWestern blot
1996
Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues.
Kim I, Ahn H, Zelner D, Shaw J, Lang S, Kato M, Oefelein M, Miyazono K, Nemeth J, Kozlowski J, Lee C. Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues. Clinical Cancer Research 1996, 2: 1255-61. PMID: 9816295.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IAnimalsAntibody SpecificityHumansImmunohistochemistryMaleProstatic NeoplasmsProtein Serine-Threonine KinasesRabbitsReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaTumor Cells, CulturedConceptsType II receptorHuman prostate cancer tissuesProstate cancer tissuesII receptorsProstate cancer cellsLoss of expressionTumor gradeTGF-beta receptorsCancer tissuesProstate tissueTGF-beta1 type IProstate cancer cell growthMalignant human prostate tissueType ICancer cellsHuman prostate cancer cellsGrowth factor-beta type IProstate cancer casesHuman prostate cancerBenign prostate tissueCancer cell growthHuman prostate tissueTGF-beta type IGrowth factor beta1Benign human prostate