2024
An in vivo examination of the relationship between metabotropic glutamate receptor 5 and suicide attempts in people with borderline personality disorder
Davis M, Asch R, Weiss E, Wagner A, Fineberg S, Nabulsi N, Matuskey D, Carson R, Esterlis I. An in vivo examination of the relationship between metabotropic glutamate receptor 5 and suicide attempts in people with borderline personality disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39613160, DOI: 10.1016/j.bpsc.2024.11.014.Peer-Reviewed Original ResearchBorderline personality disorderPathophysiology of borderline personality disorderSuicide attemptsPersonality disorderPositron emission tomographyAssociated with history of suicide attemptBorderline personality disorder symptomsBPD pathophysiologyPositron emission tomography outcomes measurementsHistory of suicide attemptsMetabotropic glutamate receptor type 5Metabotropic glutamate receptor 5Glutamate receptor 5Comprehensive clinical assessmentFrontolimbic circuitsMDD groupDepressive disorderEmotion regulationPsychiatric conditionsCognitive functionMGlu5Comparison controlsMDDSuicideAssociated with history
2021
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET
Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET. NeuroImage 2021, 238: 118217. PMID: 34052464, PMCID: PMC8378132, DOI: 10.1016/j.neuroimage.2021.118217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingBrain ChemistryFemaleFluorine RadioisotopesFluorodeoxyglucose F18Gray MatterHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingOrgan SizePositron-Emission TomographyRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5Young AdultConceptsMetabotropic glutamate receptor subtype 5MGluR5 availabilityMultiple brain regionsTissue lossSubtype 5Association cortexPrimary analysisBrain regionsAge-related molecular changesBrain glutamatergic systemBrain tissue lossNon-significant trendPartial volume correctionPositron emission tomographyBrain mGluR5Effect of ageAge-related declineGlutamatergic systemInverse associationTissue alterationsDistribution volumeEmission tomographyOlder ageCognitive functionExploratory analysisAcute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder
Davis MT, DellaGiogia N, Maruff P, Pietrzak RH, Esterlis I. Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder. Translational Psychiatry 2021, 11: 205. PMID: 33833217, PMCID: PMC8032778, DOI: 10.1038/s41398-021-01327-5.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionStress disorderCognitive functionSingle-dose intravenous ketamineAcute cognitive effectsLarge magnitude improvementsPTSD relativeCognitive measuresCognitive domainsPTSD individualsMemory performanceCognitive effectsYears of educationBaseline performanceCognitive declineHealthy controlsPsychiatric distressCognitive dysfunctionHC individualsHC groupDepressive symptomsMemory 2Subanesthetic doseMajor depressive
2020
Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise
Pitts BL, Wen V, Whealin JM, Fogle BM, Southwick SM, Esterlis I, Pietrzak RH. Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise. American Journal Of Geriatric Psychiatry 2020, 28: 959-967. PMID: 32122804, DOI: 10.1016/j.jagp.2020.02.001.Peer-Reviewed Original ResearchConceptsU.S. military veteransVisual learningCognitive functioningMet allele carriersMilitary veteransObjective measuresSubjective cognitive measuresSubjective measuresCognitive dysfunctionEffect of depressionVal66Met genotypeCognitive measuresCognitive AssessmentProcessing speedCognitive functionBDNF Val66Met polymorphismPhysical exerciseVal/ValBDNF Val66Met genotypeFunctioningTreatment effortsModerate decrementsAnalysis of covarianceInteractive effectsLearning