2020
Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases
Kahlenberg JM, Kang I. Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases. Arthritis & Rheumatology 2020, 72: 386-395. PMID: 31562704, PMCID: PMC7050400, DOI: 10.1002/art.41127.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInflammasome activationRheumatic diseasesAutoimmune diseasesIL-18IL-1βClinicopathologic significanceProcaspase-1Damage-associated molecular patternsSystemic lupus erythematosusAdaptive immune pathwaysCrystal-induced arthropathiesCytokines IL-1βDevelopment of inflammationLocal inflammatory responseHost immune responsePrimary target organActive IL-1βActive caspase-1Inflammatory damageLupus erythematosusImmune toleranceRheumatoid arthritisSjögren's syndromePathogenic role
2013
Self Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies
Shin MS, Kang Y, Lee N, Wahl ER, Kim SH, Kang KS, Lazova R, Kang I. Self Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies. The Journal Of Immunology 2013, 190: 1407-1415. PMID: 23315075, PMCID: PMC3563755, DOI: 10.4049/jimmunol.1201195.Peer-Reviewed Original ResearchConceptsIL-1β productionIL-1βHuman monocytesReactive oxygen speciesOligomerization domain-like receptor family pyrinCell responsesProinflammatory cytokines IL-1βTh17 cell responseIL-17 productionAnti-dsDNA antibodiesSystemic lupus erythematosusInnate immune cellsAnti-dsDNA AbsPathogenesis of lupusCytokines IL-1βLupus pathogenesisLupus patientsFamily pyrinLupus erythematosusAutoimmune responseCutaneous lesionsImmune cellsT cellsNuclear AgsPathogenic hallmark