2023
Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2013
Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083)
Shin M, Kang Y, Lee N, Kim S, Kang K, Lazova R, Kang I. Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083). The Journal Of Immunology 2013, 190: 127.13-127.13. DOI: 10.4049/jimmunol.190.supp.127.13.Peer-Reviewed Original ResearchIL-1β productionAnti-dsDNA antibodiesIL-1βHuman monocytesReactive oxygen speciesCell responsesIL-1β dependent mannerPro-inflammatory cytokines IL-1βPeripheral blood mononuclear cellsSelf-nuclear antigensIL-17 productionSystemic lupus erythematosusInnate immune cellsBlood mononuclear cellsPathogenesis of lupusAntibody-positive seraCytokines IL-1βLupus pathogenesisLupus patientsLupus erythematosusAutoimmune responseCutaneous lesionsMononuclear cellsImmune cellsNLRP3 inflammasomeSelf Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies
Shin MS, Kang Y, Lee N, Wahl ER, Kim SH, Kang KS, Lazova R, Kang I. Self Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies. The Journal Of Immunology 2013, 190: 1407-1415. PMID: 23315075, PMCID: PMC3563755, DOI: 10.4049/jimmunol.1201195.Peer-Reviewed Original ResearchConceptsIL-1β productionIL-1βHuman monocytesReactive oxygen speciesOligomerization domain-like receptor family pyrinCell responsesProinflammatory cytokines IL-1βTh17 cell responseIL-17 productionAnti-dsDNA antibodiesSystemic lupus erythematosusInnate immune cellsAnti-dsDNA AbsPathogenesis of lupusCytokines IL-1βLupus pathogenesisLupus patientsFamily pyrinLupus erythematosusAutoimmune responseCutaneous lesionsImmune cellsT cellsNuclear AgsPathogenic hallmark
2011
Age-associated alteration in naive and memory Th17 cell response in humans
Lee JS, Lee WW, Kim SH, Kang Y, Lee N, Shin MS, Kang SW, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans. Clinical Immunology 2011, 140: 84-91. PMID: 21489886, PMCID: PMC3115516, DOI: 10.1016/j.clim.2011.03.018.Peer-Reviewed Original ResearchConceptsIL-17 productionT cellsCell responsesIL-17-producing cellsMemory cell subsetsHealthy elderly peopleHealthy young peopleAge-associated alterationsIL-17Results of ELISAEffector cellsCell subsetsDecreased frequencyHost defenseFlow cytometrySimilar findingsElderly peopleSimilar frequencyIFNCellsHumansFindingsELISAYoung peopleCytometry
2010
Age-associated alteration in naive and memory Th17 cell response in humans (85.8)
Lee J, Lee W, Kim S, Kang S, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans (85.8). The Journal Of Immunology 2010, 184: 85.8-85.8. DOI: 10.4049/jimmunol.184.supp.85.8.Peer-Reviewed Original ResearchRisk of infectionT cellsIL-17Naive CD4Peripheral bloodCell responsesIL-17-producing CD4IL-17-producing cellsFrequency of IFNTh17-polarizing cytokinesT cell immunityIFN-γ levelsT cell subsetsPMA/ionomycin stimulationAge-associated alterationsT cell receptorTh17 cellsCell immunityMemory CD4Tissue culture supernatantsAutoimmune diseasesCell subsetsMemory subsetsCD4Extracellular microorganismsDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune responseDefective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients