2017
Genetic and Epigenetic Considerations in iPSC Technology
Tanaka Y, Park I. Genetic and Epigenetic Considerations in iPSC Technology. 2017, 51-86. DOI: 10.1201/b21629-3.Peer-Reviewed Original ResearchInduced pluripotent stem cell reprogrammingMethylation patternsN-terminal tail domainsHigher-order structure of chromatinInduced pluripotent stem cellsSomatic cellsDNA methylation patternsStructure of chromatinDeoxyribonucleic acidEfficiency of iPSC generationPosttranslational modificationsEpigenetic modificationsHistone octamerDNA wrappingEpigenetic changesHigher-order structureSomatic reprogrammingEpigenetic modulationEpigenetic considerationsReprogrammingHistonePluripotent statePluripotent stem cellsIPSC generationOriginal somatic cells
2016
Dnmt1 regulates the myogenic lineage specification of muscle stem cells
Liu R, Kim KY, Jung YW, Park IH. Dnmt1 regulates the myogenic lineage specification of muscle stem cells. Scientific Reports 2016, 6: 35355. PMID: 27752090, PMCID: PMC5082760, DOI: 10.1038/srep35355.Peer-Reviewed Original ResearchConceptsImportant epigenetic markKnockout mouse approachesDNA methylation patternsMuscle stem cellsDaughter DNA strandsDNMT1 regulationEpigenetic marksLineage specificationCellular identityDNA methylationMethylation patternsDNMT1 depletionMyogenic genesMyogenic differentiationLineage fidelityNegative regulatorGene expressionDNMT1Osteogenic lineageFunctional roleFunctional consequencesMouse approachDNA strandsId-1Stem cells