2023
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responses
2019
MEF2 and the Right Ventricle: From Development to Disease
Clapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. MEF2 and the Right Ventricle: From Development to Disease. Frontiers In Cardiovascular Medicine 2019, 6: 29. PMID: 30984767, PMCID: PMC6448530, DOI: 10.3389/fcvm.2019.00029.Peer-Reviewed Original ResearchPulmonary arterial hypertensionArterial hypertensionRight ventricleRight ventricular functionLife-limiting diseaseNovel therapeutic strategiesRight ventricular developmentEndothelial dysfunctionVentricular functionTherapeutic strategiesLeft ventricleHypertensionVentricleDisease statesVentricular developmentNormal physiologyMEF2 transcription factorsDiseaseAfterloadDysfunctionTranscription factors