2023
Understanding veteran barriers to specialty outpatient PTSD clinical care
Rozek D, Steigerwald V, Baker S, Gross G, Maieritsch K, Hoff R, Harpaz-Rotem I, Smith N. Understanding veteran barriers to specialty outpatient PTSD clinical care. Journal Of Anxiety Disorders 2023, 95: 102675. PMID: 36854224, DOI: 10.1016/j.janxdis.2023.102675.Peer-Reviewed Original ResearchConceptsSpecialty outpatient clinicsPosttraumatic stress disorderOutpatient clinicPTSD specialty clinicClinical characteristicsMale sexPTSD symptom severitySpecialty clinicWhite raceClinical careClinical concernTreatment engagementSymptom severityStress disorderClinicGreater likelihoodVeteransSignificant minorityTreatmentImpact of demographicsMulti-faceted barriersCareFiscal year 2019DemographicsNational sampleUnderlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials
Zilcha-Mano S, Duek O, Suarez-Jimenez B, Zhu X, Lazarov A, Helpman L, Korem N, Malka M, Harpaz-Rotem I, Neria Y. Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials. Biological Psychiatry Global Open Science 2023, 3: 867-874. PMID: 37881552, PMCID: PMC10593870, DOI: 10.1016/j.bpsgos.2023.01.005.Peer-Reviewed Original ResearchPosttraumatic stress disorderRight hippocampal volumeHippocampal volumeSymptom reductionPosttreatment magnetic resonance imagingPosttraumatic stress disorder treatment outcomeLarger hippocampal volumesDisorder treatment outcomesPTSD symptom reductionMagnetic resonance imagingGreater PTSD symptom reductionBetter prognosisClinical trialsTreatment outcomesDepressive symptomsTherapeutic outcomesPTSD treatmentResonance imagingTreatment studiesClinical targetsStress disorderPTSD symptomsSmall sample sizeHippocampal mechanismsTreatment
2022
Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans
Spiller TR, Duek O, Buta E, Gross G, Smith NB, Harpaz-Rotem I. Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans. Psychological Medicine 2022, 53: 4561-4568. PMID: 35959560, PMCID: PMC10388318, DOI: 10.1017/s0033291722001441.Peer-Reviewed Original ResearchConceptsGroup cognitive processing therapyCognitive processing therapyPosttraumatic stress disorderIndividual cognitive processing therapyPTSD symptom severitySymptom severityStress disorderReal-world effectivenessComparative effectiveness studiesResidential treatmentEffective treatmentComparative effectivenessVeterans AffairsEffectiveness studiesPTSD ChecklistPTSD severityGroup therapySeverityVeteransTreatmentDSM-5Group V.TherapyDisordersSmall reduction
2021
A preliminary investigation of VA PTSD residential treatment for veterans admitted from unstable housing or incarceration
Holliday R, Gross G, Desai A, Smith N, Harpaz-Rotem I. A preliminary investigation of VA PTSD residential treatment for veterans admitted from unstable housing or incarceration. Journal Of Social Distress And The Homeless 2021, 31: 238-243. DOI: 10.1080/10530789.2021.1926750.Peer-Reviewed Original ResearchResidential Rehabilitation Treatment ProgramDepressive symptomsUnstable housingPTSD symptomsJustice-involved veteransPost-discharge careRehabilitation treatment programPrison/jailSymptom recurrenceJail/prisonPTSD treatmentSymptomsTreatment programFour monthsVeteransResidential treatmentAdmissionRecurrenceExperienced reductionsSignificant changesTreatmentUnderstanding of factorsIn Their Own Words: Veteran Experiences with Evidence-Based Treatments for PTSD in the Veterans Health Administration
Doran JM, O’Shea M, Harpaz-Rotem I. In Their Own Words: Veteran Experiences with Evidence-Based Treatments for PTSD in the Veterans Health Administration. Psychiatric Quarterly 2021, 92: 961-980. PMID: 33409926, DOI: 10.1007/s11126-020-09861-z.Peer-Reviewed Original ResearchConceptsVeterans Affairs Healthcare SystemEvidence-based psychotherapiesVeterans Health AdministrationEvidence-based treatmentsOutpatient PTSD clinicVeterans' experiencesTreatment completionTreatment outcomesPTSD clinicTreatment protocolHealth AdministrationHealthcare systemTreatmentPTSDOutcomesVeteransVeterans' perceptionsMultiple barriersTreatment dropAssessment toolPresent study
2018
In Their Own Words: Clinician Experiences and Challenges in Administering Evidence-Based Treatments for PTSD in the Veterans Health Administration
Doran JM, O’Shea M, Harpaz-Rotem I. In Their Own Words: Clinician Experiences and Challenges in Administering Evidence-Based Treatments for PTSD in the Veterans Health Administration. Psychiatric Quarterly 2018, 90: 11-27. PMID: 30209719, DOI: 10.1007/s11126-018-9604-5.Peer-Reviewed Original ResearchConceptsVeterans Affairs Healthcare SystemEvidence-based psychotherapiesClinician experienceVeteran populationVeterans Health AdministrationOutpatient PTSD clinicClinicians' perceptionsPTSD clinicClinical practiceHealth AdministrationTreatment effectivenessHealthcare systemPTSDTreatmentOne-hour focus groupsCliniciansRepresentative quotesPresent studyFocus groupsActive ingredientsChange/improvementClinicPopulation
2017
Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic
Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports 2017, 19: 74. PMID: 28844076, PMCID: PMC5904792, DOI: 10.1007/s11920-017-0829-z.Peer-Reviewed Original ResearchConceptsSynaptic connectivityRapid-acting treatmentPathophysiology of PTSDPotential clinical importanceTreatment of PTSDSynaptic lossPurpose of ReviewStudiesDisconnection syndromeClinical importanceNovel pharmacotherapeuticsNovel therapeuticsPTSD symptomsRecent FindingsHerePTSDPathophysiologyKetamineTreatmentDisordersTherapeutic applicationsStress-related lossesSyndromeSymptomsPharmacotherapeutics
2014
Determinants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans
Harpaz-Rotem I, Rosenheck RA, Pietrzak RH, Southwick SM. Determinants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans. The Journal Of Nervous And Mental Disease 2014, 202: 97-104. PMID: 24469520, DOI: 10.1097/nmd.0000000000000078.Peer-Reviewed Original ResearchConceptsMental health treatmentPosttraumatic stress disorderIraq/Afghanistan veteransHealth treatmentAfghanistan veteransSymptomatic veteransMental health visitsMental health screeningMental health statusMental health servicesHealth visitsHealth screeningService utilizationRe-experiencing symptomsDepressive symptomsHealth statusHealth servicesPsychosocial determinantsStress disorderSymptomsVeteransTreatmentConsistent determinantsNumbing symptomsProspective engagement
2009
Tracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs
Harpaz-Rotem I, Rosenheck RA. Tracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs. JAMA Psychiatry 2009, 66: 417-421. PMID: 19349311, DOI: 10.1001/archgenpsychiatry.2008.536.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHealth care systemVeterans AffairsStress disorderSound Health Care SystemCare systemUse of prazosinPercentage of patientsTreatment of patientsTreatment of nightmaresPrazosin usePatient characteristicsNational health care systemMedical CenterMAIN OUTCOMEPrazosinPassive disseminationPatientsClinical practiceNew treatmentsPassive diffusionPrazosin hydrochlorideFiscal year 2004TreatmentPreliminary evidence