2023
Clinical Outcomes of Veterans Affairs Residential PTSD Treatment for PTSD and Depressive Symptoms: 1-Year Follow-Up Outcomes and Gender Differences
Gross G, Spiller T, Carretta R, Sippel L, Smith N, Harpaz-Rotem I. Clinical Outcomes of Veterans Affairs Residential PTSD Treatment for PTSD and Depressive Symptoms: 1-Year Follow-Up Outcomes and Gender Differences. Psychological Trauma Theory Research Practice And Policy 2023, 15: 1406-1415. PMID: 37199985, DOI: 10.1037/tra0001494.Peer-Reviewed Original ResearchPosttraumatic stress disorderResidential Rehabilitation Treatment ProgramDepressive symptomsWomen veteransTime pointsTreatment gainsRehabilitation treatment programResidential treatmentDepressive symptom severityGreater symptom reductionFirst national investigationLong-term effectivenessResidential PTSD treatmentClinical outcomesYear postdischargeUp OutcomesSymptom reductionPTSD treatmentSymptom changeSymptom severitySymptomsTreatment programStress disorderPTSD symptomsLinear mixed modelsComparative effectiveness of evidence-based psychotherapies for PTSD delivered in VA residential PTSD treatment
Sippel L, Gross G, Spiller T, Duek O, Smith N, Hoff R, Harpaz-Rotem I. Comparative effectiveness of evidence-based psychotherapies for PTSD delivered in VA residential PTSD treatment. Psychological Medicine 2023, 53: 6859-6866. PMID: 36971021, DOI: 10.1017/s0033291723000375.Peer-Reviewed Original ResearchResidential Rehabilitation Treatment ProgramPosttraumatic stress disorderCognitive processing therapyComparative effectivenessProlonged exposureFirst-line treatmentSevere posttraumatic stress disorderRehabilitation treatment programSelf-reported posttraumatic stress disorderDepressive symptom outcomesDepressive symptom severityEvidence-based psychotherapiesElectronic medical recordsResidential PTSD treatmentSymptomatic patientsComorbid conditionsMedical recordsPE groupSymptom outcomesIndividual cognitive processing therapyDepressive symptomsPTSD treatmentSymptom severityTreatment programProgram evaluation dataUnderlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials
Zilcha-Mano S, Duek O, Suarez-Jimenez B, Zhu X, Lazarov A, Helpman L, Korem N, Malka M, Harpaz-Rotem I, Neria Y. Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials. Biological Psychiatry Global Open Science 2023, 3: 867-874. PMID: 37881552, PMCID: PMC10593870, DOI: 10.1016/j.bpsgos.2023.01.005.Peer-Reviewed Original ResearchPosttraumatic stress disorderRight hippocampal volumeHippocampal volumeSymptom reductionPosttreatment magnetic resonance imagingPosttraumatic stress disorder treatment outcomeLarger hippocampal volumesDisorder treatment outcomesPTSD symptom reductionMagnetic resonance imagingGreater PTSD symptom reductionBetter prognosisClinical trialsTreatment outcomesDepressive symptomsTherapeutic outcomesPTSD treatmentResonance imagingTreatment studiesClinical targetsStress disorderPTSD symptomsSmall sample sizeHippocampal mechanismsTreatmentIdentifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study.
Fischer I, Feldman D, Tsai J, Harpaz-Rotem I, Lucas K, Schulenberg S, Pietrzak R. Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study. International Psychogeriatrics 2023, 35: 560-565. PMID: 36715004, DOI: 10.1017/s1041610222001223.Peer-Reviewed Original ResearchConceptsUS military veteransNational HealthMilitary veteransSignificant correlatesOlder US veteransAdverse health outcomesModifiable psychosocial factorsAdverse outcomesElastic net analysisUS veteransDepressive symptomsPsychosocial factorsHealth outcomesVeterans StudyPsychosocial variablesTreatment effortsCognitive outcomesCross-sectional dataVeteransOutcomesSocial supportCommunity integrationImportant correlatesHealthCorrelates
2021
A preliminary investigation of VA PTSD residential treatment for veterans admitted from unstable housing or incarceration
Holliday R, Gross G, Desai A, Smith N, Harpaz-Rotem I. A preliminary investigation of VA PTSD residential treatment for veterans admitted from unstable housing or incarceration. Journal Of Social Distress And The Homeless 2021, 31: 238-243. DOI: 10.1080/10530789.2021.1926750.Peer-Reviewed Original ResearchResidential Rehabilitation Treatment ProgramDepressive symptomsUnstable housingPTSD symptomsJustice-involved veteransPost-discharge careRehabilitation treatment programPrison/jailSymptom recurrenceJail/prisonPTSD treatmentSymptomsTreatment programFour monthsVeteransResidential treatmentAdmissionRecurrenceExperienced reductionsSignificant changesTreatmentUnderstanding of factors
2014
Comparing four competing models of depressive symptomatology: A confirmatory factor analytic study of 986,647 U.S. veterans
Tsai J, Elhai JD, Pietrzak RH, Hoff RA, Harpaz-Rotem I. Comparing four competing models of depressive symptomatology: A confirmatory factor analytic study of 986,647 U.S. veterans. Journal Of Affective Disorders 2014, 165: 166-169. PMID: 24882195, DOI: 10.1016/j.jad.2014.04.075.Peer-Reviewed Original ResearchConceptsNon-somatic factorsU.S. veteransDepressive symptomsDepressive symptomatologyNon-veteran samplesSymptom-level dataMajor depressive symptomsMajor depression diagnosisMajor depression symptomsFeelings of worthlessnessAppetite changesPsychomotor agitationThoughts of deathDepression diagnosisMajor depressionSleep difficultiesClinical relevanceClinician-administered measuresCurrent diagnostic systemsDepression symptomsConcentration difficultiesSomatic factorsDepressed moodSymptomsVeteransDeterminants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans
Harpaz-Rotem I, Rosenheck RA, Pietrzak RH, Southwick SM. Determinants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans. The Journal Of Nervous And Mental Disease 2014, 202: 97-104. PMID: 24469520, DOI: 10.1097/nmd.0000000000000078.Peer-Reviewed Original ResearchConceptsMental health treatmentPosttraumatic stress disorderIraq/Afghanistan veteransHealth treatmentAfghanistan veteransSymptomatic veteransMental health visitsMental health screeningMental health statusMental health servicesHealth visitsHealth screeningService utilizationRe-experiencing symptomsDepressive symptomsHealth statusHealth servicesPsychosocial determinantsStress disorderSymptomsVeteransTreatmentConsistent determinantsNumbing symptomsProspective engagement
2011
Examining the dimensionality of combat-related posttraumatic stress and depressive symptoms in treatment-seeking OEF/OIF/OND veterans
Tsai J, Pietrzak RH, Southwick SM, Harpaz-Rotem I. Examining the dimensionality of combat-related posttraumatic stress and depressive symptoms in treatment-seeking OEF/OIF/OND veterans. Journal Of Affective Disorders 2011, 135: 310-314. PMID: 21782249, DOI: 10.1016/j.jad.2011.06.057.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAfghan Campaign 2001-BehaviorDepressionDepressive DisorderDisability EvaluationEthnicityFactor Analysis, StatisticalHumansIraq War, 2003-2011Military PersonnelPatient Acceptance of Health CareResilience, PsychologicalSocial SupportStress Disorders, Post-TraumaticSurveys and QuestionnairesVeteransVeterans Disability ClaimsConceptsPosttraumatic Stress Disorder Checklist-Military versionOEF/OIF/OND veteransPosttraumatic stress disorderFour-factor solutionCognitive copingPsychological resilienceStress disorderAlcohol useSocial supportCombat-related posttraumatic stress disorderTreatment-seeking veteransDimensionality of itemsDepressive symptomsPosttraumatic stressOperations Enduring Freedom/Iraqi Freedom/New DawnExploratory factor analysisPatient Health Questionnaire-9Cross-sectional designSymptom structureMore varianceFactor structureBodily disturbancesDetachment/Cluster of symptomsFactor scores