2023
Long term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculus
2021
Religion, spirituality, and risk for incident posttraumatic stress disorder, suicidal ideation, and hazardous drinking in U.S. military veterans: A 7-year, nationally representative, prospective cohort study
Rubenstein A, Koenig HG, Marin DB, Sharma V, Harpaz-Rotem I, Pietrzak RH. Religion, spirituality, and risk for incident posttraumatic stress disorder, suicidal ideation, and hazardous drinking in U.S. military veterans: A 7-year, nationally representative, prospective cohort study. Journal Of Affective Disorders 2021, 295: 1110-1117. PMID: 34706422, DOI: 10.1016/j.jad.2021.08.128.Peer-Reviewed Original ResearchConceptsNon-organizational religious activityProspective cohort studyOrganizational religious activityHazardous drinkingSuicidal ideationMental health outcomesU.S. military veteransCohort studyHealth outcomesMilitary veteransIncident posttraumatic stress disorderMultivariable logistic regression analysisLogistic regression analysisMental health assessmentPosttraumatic stress disorderCross-sectional designPositive mental health outcomesLower incidenceLower riskSociodemographic factorsClinical implicationsGreater riskStress disorderHealth assessmentRegression analysis
2020
The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions
Fogle BM, Tsai J, Mota N, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions. Frontiers In Psychiatry 2020, 11: 538218. PMID: 33362593, PMCID: PMC7755975, DOI: 10.3389/fpsyt.2020.538218.Peer-Reviewed Original ResearchNational HealthVeterans StudyMental disordersNarrative reviewVeterans Affairs Healthcare SystemPopulation-based dataUnique health needsUnited States veteransPost-traumatic stress disorderNon-veteran counterpartsPost-traumatic growthProtective psychosocial characteristicsProspective studyStates veteransIndependent cohortHealth outcomesHealth needsU.S. veteransCare deliveryClinical implicationsLongitudinal changesPsychosocial characteristicsProtective factorsStress disorderTreatment efforts