2023
Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome. Journal Of Applied Physiology 2023, 134: 868-878. PMID: 36861670, DOI: 10.1152/japplphysiol.00583.2022.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeEndothelial dysfunctionEndothelial functionOvary syndromeAndrogen excessLean womenObese womenEstradiol supplementationLow flow-mediated constrictionOW/OB groupOverweight/obese womenMarked endothelial dysfunctionSevere endothelial dysfunctionFree testosterone levelsBody mass indexFlow-mediated dilation (FMD) testFree testosteroneMass indexReactive hyperemiaOB groupTestosterone levelsHealth differEndothelial pathophysiologyDysfunctionAndrogens
2022
Endothelial (Dys)function in Women With Androgen Excess Polycystic Ovary Syndrome: Effects of Body Composition and Ethinyl Estradiol Supplementation
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Endothelial (Dys)function in Women With Androgen Excess Polycystic Ovary Syndrome: Effects of Body Composition and Ethinyl Estradiol Supplementation. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.0r847.Peer-Reviewed Original ResearchOW/OB womenFlow-mediated dilationPolycystic ovary syndromeOB womenEndothelial functionEndothelial dysfunctionLean womenOvary syndromeEstradiol supplementationForms of PCOSConduit vessel endothelial functionOverweight/obese womenHealthy lean womenImpaired endothelial functionResult of obesityVessel endothelial functionFMD changesFMD responseObese womenFree testosteroneOb controlsReactive hyperemiaBody compositionEE supplementationDysfunction
2017
Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman C, Taylor H, Stachenfeld N. Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.5.Peer-Reviewed Original ResearchPolycystic ovary syndromeLean polycystic ovary syndromeObese PCOS womenCutaneous vascular conductanceNitric oxide inhibitionObese womenET-1PCOS womenOvary syndromeVasodilatory responseEndothelial functionOxide inhibitionEndothelin receptor subtype BObese polycystic ovary syndromeIntradermal microdialysis perfusionCardiovascular risk factorsMicrovascular endothelial functionPlasma endothelin-1Adverse cardiovascular outcomesAmerican Heart AssociationEndothelin B receptorLaser Doppler flowmetryDose-response curveCardiovascular outcomesIndependent vasodilation