2018
Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker
Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker. Clinical Neurophysiology 2018, 130: 280-288. PMID: 30605890, DOI: 10.1016/j.clinph.2018.11.016.Peer-Reviewed Original ResearchConceptsLocalization related epilepsyEpilepsy networkSeizure onset locationSingle-patient levelCorrelated network activityPatient-specific biomarkersRelated epilepsyConnectivity patternsNeocortical epilepsyPatient levelSeizure onsetInterictal periodAnatomic locationPatientsPossible biomarkersState connectivityCortical regionsSingle-subject levelTopographic distributionCohortNetwork disorderBrain networksEpilepsyNetwork activityBiomarkers
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordings
2007
Neocortical and Thalamic Spread of Amygdala Kindled Seizures
Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. Neocortical and Thalamic Spread of Amygdala Kindled Seizures. Epilepsia 2007, 48: 254-262. PMID: 17295618, DOI: 10.1111/j.1528-1167.2006.00934.x.Peer-Reviewed Original ResearchConceptsFrontal cortexMedial thalamusInterictal periodNervous systemSimultaneous field potential recordingsAmygdala-Kindled SeizuresResult of kindlingDevelopment of epilepsyNetwork plasticityField potential recordingsSeizure durationBehavioral seizuresMotor seizuresKindled SeizuresAmygdala kindlingEpilepsy modelSeizuresKindlingPotential recordingsNeocortical circuitsCortexBehavioral severityWeak stimulationThalamusPossible role