2009
IMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy
Pan J, Williamson A, Cavus I, Zaveri H, Spencer D, Hetherington H. IMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy. 2009, 1568-1573. DOI: 10.1016/b978-012373961-2.00222-8.Peer-Reviewed Original ResearchHuman epilepsyNAA/Cr ratioMetabolic imagingPCr/ATP ratioLocalization/lateralizationMR spectroscopic studiesEpileptic hippocampusMicrodialysis measuresPathophysiologic correlatesSeizure focusNeuropsychologic dataExtracellular glutamateMetabolic dysfunctionMetabolic pathophysiologyVivo MR spectroscopyElectrophysiological functionPhysiologic correlatesEpilepsyMR spectroscopic measurementsMR spectroscopyCr ratioMitochondrial functionMR spectroscopicMemory functionHuman brain
2008
Neurometabolism in human epilepsy
Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OA, Spencer DD. Neurometabolism in human epilepsy. Epilepsia 2008, 49: 31-41. PMID: 18304254, PMCID: PMC3657747, DOI: 10.1111/j.1528-1167.2008.01508.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain DiseasesBrain MappingCarbon IsotopesDominance, CerebralElectrodes, ImplantedElectroencephalographyEpilepsyGamma-Aminobutyric AcidGlucoseHippocampusHumansLimbic SystemMagnetic Resonance SpectroscopyMetabolic DiseasesMicrodialysisMitochondrial DiseasesNeural PathwaysNeuronsPositron-Emission TomographyRatsSynaptic TransmissionConceptsNeurometabolic dysfunctionMagnetic resonance spectroscopic imagingHuman epilepsyEpileptic brainHippocampal resectionSclerotic hippocampusPathophysiologic aspectsEpileptogenic processMicrodialysis measuresExtracellular glutamateEpileptic dysfunctionEnergetic dysfunctionHuman studiesDysfunctionNeurotransmitter cyclingNoninvasive functional imagingProfound decreaseMitochondrial injuryBrain functionEpilepsyFunctional imagingMetabolic imagingBrainIntracranial EEGNeurometabolism