2024
Stability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bands
2022
331 Role of Functional Network Formation in Epilepsy
Boddeti U, Bachani M, Moyer M, Owotade J, Serra R, Zaveri H, Ksendzovsky A. 331 Role of Functional Network Formation in Epilepsy. Neurosurgery 2022, 68: 75-76. DOI: 10.1227/neu.0000000000001880_331.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEpileptogenic focusFocal epilepsyTetanic stimulationGood surgical outcomePrimary mixed culturesMulti-electrode arraysCortical epilepsyRefractory seizuresSurgical resectionSurgical outcomesEpileptogenic networksVitro stimulationCortical neuronsRat pupsSeizure onsetAxonal boutonsEpilepsy patientsSurgery decisionDaily stimulationDendritic spinesSeizure formationEpilepsyVitro modelStimulationNetwork disorder
2019
Slowing less than 1 Hz is decreased near the seizure onset zone
Lundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Slowing less than 1 Hz is decreased near the seizure onset zone. Scientific Reports 2019, 9: 6218. PMID: 30996228, PMCID: PMC6470162, DOI: 10.1038/s41598-019-42347-y.Peer-Reviewed Original ResearchConceptsSeizure onset zoneOnset zoneFocal slowingFocal cerebral dysfunctionLocation of dysfunctionFocal epilepsy patientsSlow wave activitySlow oscillationsLocal synaptic strengthsSlow oscillation activityCerebral dysfunctionReduced inhibitory activityPostictal statePostictal slowingEpilepsy patientsModulatory effectsSynaptic strengthDelta frequencyCortical mechanismsIntracranial recordingsDistinct neural mechanismsIntracranial electroencephalographyNeural mechanismsDysfunctionSleep
2018
Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram
Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.Peer-Reviewed Original ResearchConceptsAED taperYale-New Haven HospitalAdult epilepsy patientsSeizure forecasting algorithmsElectrode contact pairsSeizure onset areaSeizure susceptibilityClinical recordsDrug taperElectrophysiological changesEpilepsy patientsIntracranial electroencephalographic dataMagnitude-squared coherenceModulatory activitySeizuresPatientsOnset areaPreseizurePostseizureProgressive desynchronizationIntracranial electroencephalogramDaysIctogenesisEffect of timeHospital
2016
Progressive change in sleep over multiple nights of intracranial EEG monitoring
Joshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology 2016, 127: 2302-2307. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.Peer-Reviewed Original Research
2013
Seizure localization using three-dimensional surface projections of intracranial EEG power
Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-626. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.Peer-Reviewed Original ResearchConceptsEpilepsy surgerySeizure localizationGood surgical outcomeEEG powerIntractable epilepsy patientsAgreement rateNormal brain functionOverall agreement ratePoor outcomeSurgical outcomesIntractable epilepsyIcEEG recordingsSeizure onsetSublobar localizationEpilepsy patientsIndependent reviewersClinical informationIcEEG dataPatientsBrain functionSurgeryImproved diagnostic methodIntracranial EEGDiagnostic methodsOutcomes
2009
Intracranial EEG power and metabolism in human epilepsy
Pan JW, Zaveri HP, Spencer DD, Hetherington HP, Spencer SS. Intracranial EEG power and metabolism in human epilepsy. Epilepsy Research 2009, 87: 18-24. PMID: 19699059, PMCID: PMC2783857, DOI: 10.1016/j.eplepsyres.2009.07.006.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyNAA/CrMesial temporal lobeNeocortical epilepsySeizure onset zoneN-acetyl aspartateHigh-frequency activityTemporal lobeOnset zoneFrequency activityMetabolic imagingIntracranial EEG analysisTemporal lobe epilepsyEEG powerQuantitative EEG measuresLobe epilepsySame anatomical regionMTLE groupSeizure localizationHuman epilepsyTissue injuryEpilepsy patientsHuman studiesAbnormal manifestationsEpilepsy