2003
Memory CD4+ T cells do not induce graft-versus-host disease
Anderson BE, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik MJ, Shlomchik WD. Memory CD4+ T cells do not induce graft-versus-host disease. Journal Of Clinical Investigation 2003, 112: 101-108. PMID: 12840064, PMCID: PMC162285, DOI: 10.1172/jci17601.Peer-Reviewed Original ResearchConceptsDonor T cellsMemory CD4 cellsMemory T cellsT cellsHost diseaseCD4 cellsMemory T cell depletionPost-transplant immune reconstitutionAllogeneic stem cell transplantationT cell-mediated immunityT-cell depletionCell-mediated immunityRegulatory T cellsStem cell transplantationStem cell graftsGVHD prophylaxisHistologic GVHDLess GVHDMurine resultsImmune reconstitutionLeukemia effectMemory CD4Naive CD4Cell depletionCell transplantation
2001
Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*
Young A, Carter W, Doyle H, Mamula M, Aswad D. Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*. Journal Of Biological Chemistry 2001, 276: 37161-37165. PMID: 11479322, DOI: 10.1074/jbc.m106682200.Peer-Reviewed Original ResearchConceptsHistone H2BIsoaspartate (D-aspartate) O-methyltransferaseNormal gene regulationProtein repair enzymePIMT knockout miceActivity of proteinsRat PC12 cellsGene regulationProtein functionHistone H2B.Core histonesNuclear proteinsSubcellular fractionationProtein agingRepair enzymesH2BO-methyltransferaseAdenosine dialdehydeMethyltransferase inhibitorProtein LHistonesAsp-XaaPC12 cellsIsoAspStoichiometric levelsLupus autoantigens: Their origins, forms, and presentation
Doyle H, Yan J, Liang B, Mamula M. Lupus autoantigens: Their origins, forms, and presentation. Immunologic Research 2001, 24: 131-147. PMID: 11594452, DOI: 10.1385/ir:24:2:131.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMaintenance of autoimmunityT cell compartmentCentral lymphoid organsT cell developmentAutoimmune processLupus erythematosusAntigenic sinAutoreactive cellsAutoimmune diseasesLymphoid organsPresenting cellsB lymphocytesImmune systemAutoimmunityCell compartmentNumber of mechanismsCell developmentInductionErythematosusCellsLupusForeign proteinsLymphocytesCostimulation
2000
Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice
Buchanan K, Doyle H. Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice. Infection And Immunity 2000, 68: 456-462. PMID: 10639404, PMCID: PMC97163, DOI: 10.1128/iai.68.2.456-462.2000.Peer-Reviewed Original ResearchConceptsCentral nervous systemCell-mediated immunityImmune miceT cellsT lymphocytesNervous systemRole of CMIC. neoformansCryptococcus neoformansProtective mechanismT cell numbersSpinal cord homogenateCMI responsesCNS infectionsCryptococcal meningitisLeukocyte accumulationAIDS patientsFatal outcomeImmunized miceVivo depletionCord homogenateIFN-gammaMurine modelHost resistanceCytometric analysis
1999
Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response.
Doyle H, Murphy J. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. The Journal Of Immunology 1999, 162: 4824-33. PMID: 10202026, DOI: 10.4049/jimmunol.162.8.4824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, FungalAntigens, FungalCell MovementChemokine CCL1Chemokine CCL3Chemokine CCL4Chemokines, CCCryptococcosisCryptococcus neoformansCytokinesFemaleGelatin Sponge, AbsorbableHypersensitivity, DelayedImmunity, CellularKineticsLeukocytesMacrophage Inflammatory ProteinsMiceMice, Inbred CBANeutrophilsReceptors, CCR8Recombinant ProteinsConceptsDelayed-type hypersensitivityMIP-1alphaC chemokinesAnticryptococcal cell-mediated immune responseCell-mediated immune responsesCell-mediated immune reactionsMacrophage inflammatory protein-1alphaMonocyte chemotactic protein-1DTH reaction sitesNumber of neutrophilsActivated T lymphocytesGelatin sponge modelCMI responsesNaive miceDTH reactionInfected miceCMI reactionsT cellsT lymphocytesImmune responseImmune reactionsCellular infiltrationLymphocytesChemokinesNeutrophils
1997
MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans
Doyle H, Murphy J. MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans. Journal Of Leukocyte Biology 1997, 61: 147-155. PMID: 9021919, DOI: 10.1002/jlb.61.2.147.Peer-Reviewed Original ResearchConceptsMIP-1 alphaMIP-1 alpha levelsDelayed-type hypersensitivity reactionImmunized miceHypersensitivity reactionsC. neoformansCell-mediated immune responsesInflammatory protein-1 alphaCryptococcus neoformansAlpha levelsDTH reaction sitesInflux of neutrophilsNumber of neutrophilsProtein-1 alphaClearance of microorganismsGelatin sponge modelCMI responsesCryptococcal antigenNeutrophil influxNaive miceDTH reactionLeukocyte infiltrationMIP-1αChemotactic cytokinesImmune response