2018
Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine
You N, He S, Wang X, Zhu J, Zhang H. Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine. Biometrics 2018, 74: 814-822. PMID: 29359319, DOI: 10.1111/biom.12843.Peer-Reviewed Original ResearchConceptsRegularization regressionVariable selectionHigh-dimensional predictorsNecessary statistical methodsVariable selection methodsExpectation-maximization algorithmOracle propertyPenalty parameterSemiparametric modelStatistical methodsParametric modelNumerical calculationsProper choiceModel constructionSelection methodGene expression datasetsModelEstimatorSubtype-specific risk factorsRegularizerSurvival probabilityHigh-throughput technologiesExpression datasetsAlgorithmSimulations
2016
Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival Endpoints
Han G, Schell MJ, Zhang H, Zelterman D, Pusztai L, Adelson K, Hatzis C. Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival Endpoints. Biometrics 2016, 73: 687-695. PMID: 27669414, PMCID: PMC6093291, DOI: 10.1111/biom.12590.Peer-Reviewed Original Research
2005
Comparison of survival times in a transplant study of hematologic disorders
Fu P, Laughlin MJ, Zhang H. Comparison of survival times in a transplant study of hematologic disorders. Contemporary Clinical Trials 2005, 27: 174-182. PMID: 16326144, DOI: 10.1016/j.cct.2005.10.003.Peer-Reviewed Original ResearchConceptsHuman leucocyte antigenHematologic disordersWilcoxon testUnrelated donor graftsBone marrow transplantationLog-rank testUmbilical cord bloodEvaluation of survivalNeutrophil recoveryDonor graftsOverall survivalMarrow transplantationGraft sourceCancer patientsPatient populationClinical trialsEffective therapyHematologic malignanciesLeucocyte antigenCord bloodLog rankSurvival timePatientsPatient samplesTransplantation studies