2020
Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomes
Chen V, Zhang H. Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomes. Biostatistics 2020, 23: 157-172. PMID: 32424406, PMCID: PMC8759439, DOI: 10.1093/biostatistics/kxaa021.Peer-Reviewed Original Research
2014
Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial
Shi Y, Wei D, Liang X, Sun Y, Liu J, Cao Y, Zhang B, Legro RS, Zhang H, Chen ZJ. Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial. Trials 2014, 15: 154. PMID: 24885793, PMCID: PMC4022358, DOI: 10.1186/1745-6215-15-154.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferElective embryo cryopreservationFresh embryo transferLive birth rateEmbryo transferPCOS patientsPregnancy complicationsOocyte retrievalClinical trialsEmbryo cryopreservationMethods/designThis studyInfertile PCOS patientsClinical pregnancy ratePolycystic ovary syndromeFrozen embryo transferIntracytoplasmic sperm injectionBirth rateOvary syndromePregnancy outcomesPrimary outcomeAbnormal implantationPregnancy lossParallel groupPregnancy rateGroup B
2012
The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome
Legro RS, Kunselman AR, Brzyski RG, Casson PR, Diamond MP, Schlaff WD, Christman GM, Coutifaris C, Taylor HS, Eisenberg E, Santoro N, Zhang H, Network F. The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemporary Clinical Trials 2012, 33: 470-481. PMID: 22265923, PMCID: PMC3312939, DOI: 10.1016/j.cct.2011.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic AgentsChi-Square DistributionClomipheneDouble-Blind MethodFemaleFertility Agents, FemaleHealth Status IndicatorsHirsutismHumansHyperandrogenismInfertility, FemaleLetrozoleMiddle AgedNitrilesOvulation InductionPolycystic Ovary SyndromePregnancyQuality of LifeResearch DesignTriazolesWomen's HealthYoung AdultConceptsPolycystic ovary syndromeClomiphene citrateOvary syndromeInfertile womenTreatment armsDouble-blind clinical trialSelective estrogen receptor modulatorsMajor infertility factorOral clomiphene citrateMultiple pregnancy rateFirst-line treatmentLive birth rateEstrogen receptor modulatorsDifferent treatment armsTreatment of infertilityPoor ovulatory responseEndometrial effectsII trialII studyLine treatmentInfertility factorsProgestin withdrawalAromatase inhibitorsClinical trialsFemale infertility
2011
Recruitment challenges of a multicenter randomized controlled varicocelectomy trial
Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H, Network R. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertility And Sterility 2011, 96: 1299-1305. PMID: 22130101, PMCID: PMC3243664, DOI: 10.1016/j.fertnstert.2011.10.025.Peer-Reviewed Original ResearchConceptsReproductive Medicine NetworkPlacebo armInfertility evaluationIntrauterine inseminationMedicine NetworkSuboptimal recruitmentClinical trial enrollmentMale infertility studiesAscertain reasonsIUI cyclesInfertile womenTrial enrollmentSurgical interventionPatient educationMAIN OUTCOMEStudy recruitmentInfertile menMale infertilityStudy participantsInfertility studiesMale partnersRecruitment challengesTrialsInadequate recruitmentFertility interventions
2007
Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools
Zhu Y, Hoffman A, Wu X, Zhang H, Zhang Y, Leaderer D, Zheng T. Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2007, 639: 80-88. PMID: 18191955, PMCID: PMC2292456, DOI: 10.1016/j.mrfmmm.2007.11.005.Peer-Reviewed Original Research
2006
Linkage analysis of longitudinal data and design consideration
Zhang H, Zhong X. Linkage analysis of longitudinal data and design consideration. BMC Genomic Data 2006, 7: 37. PMID: 16768806, PMCID: PMC1550417, DOI: 10.1186/1471-2156-7-37.Peer-Reviewed Original Research
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsionCost-effective sib-pair designs in the mapping of quantitative-trait loci.
Zhao H, Zhang H, Rotter JI. Cost-effective sib-pair designs in the mapping of quantitative-trait loci. American Journal Of Human Genetics 1997, 60: 1211-21. PMID: 9150169, PMCID: PMC1712450.Peer-Reviewed Original Research