2006
Generalized score test of homogeneity for mixed effects models
Zhu H, Zhang H. Generalized score test of homogeneity for mixed effects models. The Annals Of Statistics 2006, 34: 1545-1569. DOI: 10.1214/009053606000000380.Peer-Reviewed Original ResearchTest statisticsAsymptotic distributionRandom quadratic formsGeneralized score testQuadratic formInvariance principleScore testTest of homogeneityLatent variable modelsSimulation studyResampling procedureRestrictive assumptionsEmpirical performanceHomogeneity hypothesisTheoretical resultsVariance componentsVariable modelTest procedureBiomedical studiesMild conditionsInvarianceOverdispersionImportant problemsAssumptionsObservational data
2003
A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse