2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosal
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence