1990
Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon
Turnamian S, Binder H. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. American Journal Of Physiology 1990, 258: g492-g498. PMID: 2138421, DOI: 10.1152/ajpgi.1990.258.3.g492.Peer-Reviewed Original ResearchConceptsDietary sodium depletionBody wt-1RU 28362Receptor-specific agonistsSodium depletionPotassium secretionProximal colonDay 1Glucocorticoid receptorWT-1Cl absorptionAdministration of spironolactoneActive potassium secretionRat proximal colonSecondary hyperaldosteronismContinuous infusionAldosteroneGlucocorticoid agonistAgonistsElectrolyte transportSecretionStimulationSignificant increaseInfusionColon
1989
Characterization of aldosterone-induced potassium secretion in rat distal colon.
Sweiry J, Binder H. Characterization of aldosterone-induced potassium secretion in rat distal colon. Journal Of Clinical Investigation 1989, 83: 844-851. PMID: 2921323, PMCID: PMC303757, DOI: 10.1172/jci113967.Peer-Reviewed Original Research
1986
Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats
Halevy J, Budinger M, Hayslett J, Binder H. Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats. Gastroenterology 1986, 91: 1227-1233. PMID: 3758615, DOI: 10.1016/s0016-5085(86)80021-x.Peer-Reviewed Original ResearchConceptsElectroneutral sodium chloride absorptionElectrogenic sodium absorptionSodium chloride absorptionRole of aldosteroneSodium-depleted animalsSodium absorptionChloride absorptionAldosterone infusionDistal colonPotassium secretionAmiloride-sensitive sodium absorptionContinuous aldosterone infusionDietary sodium depletionDistal colonic mucosaElevated aldosterone levelsActive potassium secretionRat distal colonAddition of amilorideRegulation of sodiumVoltage-clamp conditionsAldosterone levelsTime-dependent mannerSodium depletionColonic mucosaAldosteroneSodium and chloride transport in the large intestine of potassium-loaded rats
Budinger M, Foster E, Hayslett J, Binder H. Sodium and chloride transport in the large intestine of potassium-loaded rats. American Journal Of Physiology 1986, 251: g249-g252. PMID: 2426972, DOI: 10.1152/ajpgi.1986.251.2.g249.Peer-Reviewed Original ResearchConceptsPotassium secretionSodium absorptionRat distal colonic mucosaElectroneutral sodium chloride absorptionPotassium loadingNa-K-ATPase activityElectrogenic sodium absorptionDistal colonic mucosaActive potassium secretionPotassium-loaded ratsNet sodium absorptionSodium chloride absorptionActive sodium transportVoltage-clamp conditionsDietary potassiumColonic functionColonic mucosaNet chloride fluxNet sodium fluxJNanetNet sodiumLarge intestineChloride fluxSodium transportIdentical increase
1985
The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading
Sandle G, Foster E, Lewis S, Binder H, Hayslett J. The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading. Pflügers Archiv - European Journal Of Physiology 1985, 403: 433-439. PMID: 2409517, DOI: 10.1007/bf00589258.Peer-Reviewed Original ResearchConceptsRat distal colonDistal colonPotassium secretionDietary potassium loadingPotassium channel blocker tetraethylammonium chlorideBasolateral membrane voltageChannel blocker tetraethylammonium chloridePotassium loadingSodium channel blocker amilorideActive potassium secretionElectrical basisEnhanced potassium secretionChannel blocker amilorideMembrane conductanceIntracellular potassium activityApical membrane resistanceMucosal additionPotassium-selective microelectrodesBasal conditionsControl tissuesTransepithelial voltageColonMembrane voltageSecretionTetraethylammonium chloride
1983
Cyclic Adenosine Monophosphate Stimulates Active Potassium Secretion in the Rat Colon
Foster E, Sandle G, Hayslett J, Binder H. Cyclic Adenosine Monophosphate Stimulates Active Potassium Secretion in the Rat Colon. Gastroenterology 1983, 84: 324-330. PMID: 6293907, DOI: 10.1016/s0016-5085(83)80130-9.Peer-Reviewed Original ResearchConceptsActive potassium secretionNormal potassium dietPotassium secretionNet potassium secretionPotassium dietCyclic adenosine monophosphateDibutyryl cyclic adenosine monophosphateRat colonAdenosine monophosphatePotassium-loaded animalsCholinergic muscarinic agonistHigh potassium dietProximal colonic mucosaCalcium-dependent processesX cm2