2008
Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"
Djurić P, Benveniste H, Wagshul M, Henn F, Enikolopov G, Maletić-Savatić M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain". Science 2008, 321: 640-640. PMID: 26380846, PMCID: PMC4576718, DOI: 10.1126/science.1156889.Peer-Reviewed Original ResearchMetabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery
Maletić-Savatić M, Vingara L, Manganas L, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul M, Henn F, Krupp L, Enikolopov G, Benveniste H, Djurić P, Pelczer I. Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery. Cold Spring Harbor Symposia On Quantitative Biology 2008, 73: 389-401. PMID: 19022759, PMCID: PMC4037147, DOI: 10.1101/sqb.2008.73.021.Peer-Reviewed Original ResearchConceptsNeural stem/progenitor cellsFunctional insightsProgenitor cellsStem/progenitor cellsNeural progenitor cellsBiomarker discoveryGenome backgroundHuman neurological diseasesLive human brainSystems metabolomicsMammalian brainVivo analysisSpecific metabolitesMetabolomics techniquesMost neurological disordersLack of biomarkersEarly pathological processesProton magnetic resonance spectroscopyOrganismsMetabolomicsPathological processesHuman brainNPC biomarkersCellsLate therapy
1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1985
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
Drejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro. Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.Peer-Reviewed Original ResearchConceptsPotassium-induced releaseGlutamatergic neuronsAspartate uptakeConditions of hypoglycemiaCultured glutamatergic neuronsTransient cerebral ischemiaHigh potassiumExtracellular glutamate contentCerebral ischemiaGlutamate releaseTransmitter poolExtracellular glutamateMicrodialysis techniqueIschemiaBrain tissuePotassium stimulationPerfusion mediumHypoglycemiaGlutamate contentNeuronsInduced increasesCellular originVivo experimentsAstrocytesPrevious reports